CAS No. 130495-35-1
| IUPAC Name | 1-[2-(4-methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl]imidazole;hydrochloride | |
|---|---|---|
| CAS Number | 130495-35-1 | |
| Molecular Formula |
C22H26N2O3.HCl |
|
| Molecular Weight (MW) | 402.91 | |
| SMILES | COC1=CC=C(C=C1)CCCOC(CN2C=CN=C2)C3=CC=C(C=C3)OC.Cl | |
| InChIKey | FWLPKVQUECFKSW-UHFFFAOYSA-N |
SKF96365 is a small-molecule inhibitor of receptor-mediated calcium entry and transient receptor potential canonical (TRPC) channels. By blocking store-operated calcium influx and TRPC activity, SKF96365 attenuates intracellular calcium signaling and downstream activation of calcium-dependent signaling pathways. Consequently, treatment with SKF96365 suppresses cell proliferation, migration, and invasive cellular phenotypes in diverse preclinical cell models. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
80 mg/mL
(198.55 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 80 mg/mL |
| Ethanol | 80 mg/mL |
| DMSO |
80 mg/mL
(198.55 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 80 mg/mL |
| Ethanol | 80 mg/mL |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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