CAS No. 1221485-83-1
Batch:
Purity:99.87
Chemical Structure
Check the
Skepinone-L
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 13-(2,4-difluoroanilino)-5-[(2R)-2,3-dihydroxypropoxy]tricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-one | |
|---|---|---|
| CAS Number | 1221485-83-1 | |
| Molecular Formula |
C24H21F2NO4 |
|
| Molecular Weight (MW) | 425.42 | |
| SMILES | C1CC2=C(C=CC(=C2)NC3=C(C=C(C=C3)F)F)C(=O)C4=C1C=CC(=C4)OCC(CO)O | |
| InChIKey | HXMGCTFLLWPVFM-GOSISDBHSA-N |
Skepinone-L is a potent and highly selective inhibitor of p38α mitogen-activated protein kinase (p38α-MAPK) with an IC50 of. By blocking p38α-MAPK activity, it disrupts downstream signaling within the MAPK pathway and suppresses the expression of pro-inflammatory cytokines such as TNF-α and IL-1β. Consequently, Skepinone-L inhibits acute inflammatory responses and attenuates cellular stress signaling in preclinical models. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
85 mg/mL
(199.8 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 85 mg/mL |
| Water | Insoluble |
| DMSO |
85 mg/mL
(199.8 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 85 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.