CAS No. 410536-97-9
Batch:
Purity:97
Chemical Structure
Check the
Sirtinol
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[(2-hydroxynaphthalen-1-yl)methylideneamino]-N-(1-phenylethyl)benzamide | |
|---|---|---|
| CAS Number | 410536-97-9 | |
| Molecular Formula |
C26H22N2O2 |
|
| Molecular Weight (MW) | 394.47 | |
| SMILES | CC(C1=CC=CC=C1)NC(=O)C2=CC=CC=C2N=CC3=C(C=CC4=CC=CC=C43)O | |
| InChIKey | UXJFDYIHRJGPFS-UHFFFAOYSA-N |
Sirtinol is a sirtuin inhibitor targeting SIRT1 and SIRT2. It blocks NAD+-dependent histone deacetylase activity without affecting class I enzymes such as HDAC1. Downstream, sirtinol attenuates Ras-MAPK signaling, impairs cellular proliferation, and induces senescence-like growth arrest and apoptosis in human cancer cells, as demonstrated by elevated senescence-associated β-galactosidase activity and caspase-3 activation. [1][2]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
23 mg/mL
(58.3 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.