CAS No. 6080-33-7

Batch: Purity:99.94
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Sinomenine hydrochloride Chemical Structure
Chemical Structure
Check the Sinomenine hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (1R,9S,10S)-3-hydroxy-4,12-dimethoxy-17-methyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5,11-tetraen-13-one;hydrochloride
CAS Number 6080-33-7
Molecular Formula

C19H23NO4.HCl
Molecular Weight (MW) 365.85
SMILES CN1CCC23CC(=O)C(=CC2C1CC4=C3C(=C(C=C4)OC)O)OC.Cl
InChIKey YMEVIMJAUHZFMW-VUIDNZEBSA-N

Ordering Information

Biological Activity

Sinomenine hydrochloride is a natural alkaloid and anti-inflammatory agent that inhibits NF-kB activation. By blocking NF-kB signaling and microglial activation, it suppresses downstream inflammatory cytokine production and attenuates neuroinflammatory pathways. This compound demonstrates protective functions in neuronal models by mitigating neurotoxicity and inflammatory responses, serving as a key research tool for investigating neurodegenerative disorders and inflammatory signaling cascades. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 73 mg/mL (199.53 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.