Clinical Trials

Simvastatin has been evaluated across numerous clinical trials spanning Early Phase 1 through Phase 4, investigating conditions ranging from cardiovascular diseases and dyslipidemias to recurrent acute pancreatitis, COVID-19-mediated olfactory disorders, and type 1 diabetes. Sponsored by academic medical centers and pharmaceutical companies, these evaluations encompass various recruitment statuses, including completed, active, terminated, and not yet recruiting studies.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT07779642 NOT_YET_RECRUITING
ARDS (Acute Respiratory Distress Syndrome); Acute Hypoxic Respiratory Failure
University of Colorado, Denver
2026-09 PHASE2
NCT07625930 NOT_YET_RECRUITING
Gastroesophageal Adenocarcinoma
McGill University Health Centre/Research Institute of the McGill University Health Centre
2027-01 PHASE2
NCT06785727 NOT_YET_RECRUITING
Ischemic Stroke; Transient Ischemic Attack
Prof. dr. Nathalie van der Velde
2025-02-01 PHASE4
NCT06030622 RECRUITING
Pancreatic Cancer Metastatic
State University of New York - Downstate Medical Center
2024-04-17 PHASE1; PHASE2
NCT03324425 ACTIVE_NOT_RECRUITING
Breast Cancer Stage IV
Baylor Breast Care Center
2020-03-04 PHASE2
NCT04133792 ACTIVE_NOT_RECRUITING
Primary Sclerosing Cholangitis
Annika Bergquist
2020-10-01 PHASE3
NCT06431919 RECRUITING
Decompensated Cirrhosis; Cirrhotic Cardiomyopathy; Cirrhosis, Liver; Left Ventricular Diastolic Dysfunction; Acute Kidney Injury
Post Graduate Institute of Medical Education and Research, Chandigarh
2025-06-10
NCT07392541 RECRUITING
Advanced Biliary Tract Carcinoma
Tongji Hospital
2026-01-30 PHASE1; PHASE2
NCT07718490 RECRUITING
Metastatic Colorectal Cancer
The First Affiliated Hospital with Nanjing Medical University
2025-09-01 PHASE2
NCT05771675 RECRUITING
Recurrent Acute Pancreatitis; Chronic Pancreatitis
Cedars-Sinai Medical Center
2024-10-24 EARLY_PHASE1
NCT06399783 NOT_YET_RECRUITING
Alopecia Areata
Assiut University
2024-10-01 PHASE4
NCT07213557 RECRUITING
Advanced or Metastatic Gastrooesophageal Carcinoma
National Cancer Institute, Naples
2026-03-13 PHASE2
NCT03131726 RECRUITING
Graves Ophthalmopathy; Thyroid Associated Ophthalmopathy; Thyroid Associated Orbitopathy
Lund University
2018-01-26 PHASE3
NCT03127631 ACTIVE_NOT_RECRUITING
Prostate Cancer; Cardiovascular Disease
McMaster University
2015-10-21
NCT07389304 NOT_YET_RECRUITING
Lipid Profile,Blood Pressure
Shaheed Benazir Bhutto University Sheringal Dir Upper
2026-03-01 PHASE1
NCT07378293 NOT_YET_RECRUITING
Diabete Mellitus; Lipid Profile
Shaheed Benazir Bhutto University Sheringal Dir Upper
2026-03-01 PHASE1
NCT07003815 NOT_YET_RECRUITING
Biliary Tract Cancer; Advanced Cancer
Tongji Hospital
2025-06 PHASE2
NCT07696585 NOT_YET_RECRUITING
Alopecia Areata
Sohag University
2026-06-28
NCT07256561 RECRUITING
Endodontically Retard Teeth; Periapical Radiolucency
Hadeer Maher Mostafa Mohamed
2025-08-10
NCT05821556 RECRUITING
Adenocarcinoma of the Pancreas
National Cancer Institute, Naples
2023-06-12 PHASE2
NCT03400826 ACTIVE_NOT_RECRUITING
Fibroid Uterus; Fibroid Tumor; Leiomyoma; Fibromyoma; Leiomyoma, Uterine
Johns Hopkins University
2018-08-20 PHASE2
NCT07692620 COMPLETED
Alveolar Ridge Atrophy; Tooth Loss
Maruwan Ali Alteer
2025-06-02
NCT07264842 RECRUITING
Pulpal Necrosis
Dow University of Health Sciences
2024-06-26 PHASE2
NCT02735707 RECRUITING
Community-acquired Pneumonia, Influenza, COVID-19
UMC Utrecht
2016-04-11 PHASE3
NCT06523465 RECRUITING
Primary Aldosteronism; Statin; Mineralocorticoid Receptor Antagonist; Hypertension
Third Military Medical University
2024-09-10 PHASE4
NCT07102979 TERMINATED
Liver Fibrosis
Chang Gung Memorial Hospital
2024-01-01
NCT06879171 NOT_YET_RECRUITING
Alveolar Ridge Preservation; Horizontal Alveolar Bone Loss; Vertical Alveolar Bone Loss; Delayed Implant; Autogenous Tooth Graft
Cairo University
2025-06-10
NCT06948747 COMPLETED
Healthy Participants
AstraZeneca
2025-05-06 PHASE1
NCT06273111 UNKNOWN
Hemangioma Skin
Joyce Teng
2024-04-01 EARLY_PHASE1
NCT07194447 COMPLETED
Dental Implants , Osseointegration , Marginal Bone Loss , Implant Stability
Maha Zuhair
2024-10-03
NCT03571802 UNKNOWN
Obesity; Hyperlipidemias
National University Hospital, Singapore
2018-06-13 PHASE4
NCT06338241 UNKNOWN
Bone Loss; Regenerative Inflammation
Mario Pérez Sayáns
2024-03-02 PHASE4
NCT05550415 RECRUITING
Triple Negative Breast Cancer; Chemotherapy Effect; Simvastatin Adverse Reaction
Indonesia University
2022-08-19 PHASE2
NCT07459972 COMPLETED
Liver Cirrhosis; Portal Hypertension Related to Cirrhosis
Kafrelsheikh University
2024-03-15 PHASE4
NCT04021498 TERMINATED
Pancreatitis Relapsing
Enrique de-Madaria
2017-09-29 PHASE3
NCT06566794 COMPLETED
Drug Interaction
Helsinki University Central Hospital
2024-08-22
NCT07031778 RECRUITING
Dimensional Changes; Bone Density
Universidad de Granada
2025-01-07 EARLY_PHASE1
NCT05613400 UNKNOWN
Diabetes Mellitus, Type 2
The University of Hong Kong
2022-04-13 PHASE4
NCT01653223 RECRUITING
Congenital Heart Disease; Heart Valve Disease
Sun Yat-sen University
2013-01
NCT04457089 COMPLETED
Recurrent Ovarian Cancer; Platinum-sensitive Ovarian Cancer
Marc Goodman
2021-01-25 EARLY_PHASE1
NCT06379958 UNKNOWN
Pharmacokinetics
Modern Biosciences Ltd
2024-04-08 PHASE1
NCT02246257 UNKNOWN
Rheumatoid Arthritis; Cardiovascular Diseases
MD, PhD, Annemarie Lyng Svensson
2014-09
NCT06178640 UNKNOWN
Healthy Volunteer
International Bio service
2024-08-13 PHASE1
NCT03387670 COMPLETED
Secondary Progressive Multiple Sclerosis (SPMS)
University College, London
2018-03-28 PHASE3
NCT04301271 COMPLETED
Depressive Disorder, Major; Obesity
Charite University, Berlin, Germany
2020-08-13 PHASE2
NCT05525013 COMPLETED
Periapical Periodontitis
Cairo University
2022-10-01
NCT05677945 UNKNOWN
Necrotic Primary Molars
Cairo University
2023-03
NCT05878158 UNKNOWN
Pulp Exposure, Dental
Ahmad Elheeny
2023-04-01 EARLY_PHASE1
NCT05771675 Not yet recruiting
Recurrent Acute Pancreatitis|Chronic Pancreatitis
Cedars-Sinai Medical Center|United States Department of Defense
2024-01 Early Phase 1
NCT05551871 UNKNOWN
Traumatic Brain Injury
Assiut University
2022-10-01
NCT04514029 ACTIVE_NOT_RECRUITING
Lymphoma
Masonic Cancer Center, University of Minnesota
2020-08-06 EARLY_PHASE1
NCT02946424 UNKNOWN
Spinal Cord Injuries; Osteoporosis
Craig Hospital
2017-07-01 PHASE2
NCT02968810 ACTIVE_NOT_RECRUITING
Cirrhosis; Hepatocellular Carcinoma
National Cancer Institute (NCI)
2017-06-21 PHASE2
NCT05542095 WITHDRAWN
Olfactory Disorder; COVID-19
Washington University School of Medicine
2023-05-01 PHASE1
NCT05542095 Withdrawn
Olfactory Disorder|COVID-19
Washington University School of Medicine|Duke University
2023-05-01 Phase 1
NCT02713945 COMPLETED
Noonan Syndrome
University Hospital, Toulouse
2017-01-25 PHASE3
NCT04973800 COMPLETED
Depression; Inflammation
University of Oxford
2021-07-05
NCT04992416 COMPLETED
Autogenous Tooth Bone Graft; Immediate Implant Placement; Simvastatin
Kafrelsheikh University
2021-09-02
NCT03780673 COMPLETED
Liver Cirrhoses
Judit Pich
2019-01-03 PHASE2; PHASE3
NCT04985201 UNKNOWN
Small Cell Lung Cancer
Shanghai Pulmonary Hospital, Shanghai, China
2021-11-01 PHASE2
NCT04824898 UNKNOWN
Intra-bony Pockets
Ain Shams University
2021-01-20 PHASE1
NCT06207682 COMPLETED
Healthy Volunteers
Amgen
2022-06-28 PHASE1
NCT04049786 UNKNOWN
Obesity; Bariatric Surgery; Roux-en Y Gastric Bypass
Natalia Valadares de Moraes
2019-06-01 PHASE4
NCT03775070 COMPLETED
Dilated Cardiomyopathy
National Taiwan University Hospital
2019-01-17 PHASE2
NCT06207682 Completed
Healthy Volunteers
Amgen
2022-06-28 Phase 1
NCT05582317 COMPLETED
Pulpitis - Irreversible
Suez Canal University
2021-05-23
NCT05657015 COMPLETED
Periodontitis
Ain Shams University
2021-09-01 PHASE4
NCT05306379 COMPLETED
Drug-drug Interaction
Aurinia Pharmaceuticals Inc.
2022-01-24 PHASE1
NCT05020405 COMPLETED
Ridge Splitting; Simvastatin; Immediate Implant
Kafrelsheikh University
2020-10-01
NCT06016218 COMPLETED
Dental Caries Extending to Pulp; Dental Implant Failed
British University In Egypt
2021-01-05 PHASE1; PHASE2
NCT04178980 UNKNOWN
Simvastatin Multiple Sclerosis
Assiut University
2020-01-01 PHASE1
NCT04698941 UNKNOWN
Small Cell Lung Cancer
Shanghai Pulmonary Hospital, Shanghai, China
2021-07-25 PHASE2
NCT04507373 TERMINATED
Muscle Cramp; Ache; Weakness, Muscle; Statin Adverse Reaction
University of Texas Southwestern Medical Center
2018-08-17 PHASE4
NCT05230472 COMPLETED
VAP - Ventilator Associated Pneumonia
Ain Shams University
2021-01-01 PHASE4
NCT02971410 WITHDRAWN
Recurrent Plasma Cell Myeloma; Refractory Plasma Cell Myeloma
Wake Forest University Health Sciences
2017-04 EARLY_PHASE1
NCT03454529 COMPLETED
Invasive Breast Carcinoma; Stage I Breast Cancer AJCC v7; Stage IA Breast Cancer AJCC v7; Stage IB Breast Cancer AJCC v7; Stage II Breast Cancer AJCC v6 and v7; Stage IIA Breast Cancer AJCC v6 and v7; Stage IIB Breast Cancer AJCC v6 and v7
Michael Simon
2018-03-09 PHASE2
NCT04652089 COMPLETED
Depression; Inflammation
University of Oxford
2020-12-03 PHASE1; PHASE2
NCT02490527 COMPLETED
Statin Intolerance
University of California, San Diego
2015-06
NCT04859452 COMPLETED
Healthy Subjects
CSPC ZhongQi Pharmaceutical Technology Co., Ltd.
2021-05-26 PHASE1
NCT02796378 UNKNOWN
Cardiovascular Disease; Diabetes Mellitus
University of Copenhagen
2016-06 PHASE4
NCT03435744 COMPLETED
Treatment Resistant Depression; Major Depressive Disorder
Pakistan Institute of Living and Learning
2019-01-01 PHASE3
NCT03134157 UNKNOWN
Infertility
Royan Institute
2016-08 PHASE3
NCT04343001 WITHDRAWN
Covid-19
London School of Hygiene and Tropical Medicine
2020-10 PHASE3
NCT02871687 COMPLETED
Healthy Subjects
Brigham and Women's Hospital
2016-04 PHASE1
NCT04348695 COMPLETED
Coronavirus Infection
Fundación de investigación HM
2020-04-12 PHASE2
NCT03510884 COMPLETED
Hypercholesterolaemia
Sanofi
2018-05-31 PHASE3
NCT02161822 UNKNOWN
Adenocarcinoma of Rectum
Samsung Medical Center
2014-10-01 PHASE2
NCT03929744 COMPLETED
Healthy
Eli Lilly and Company
2019-06-12 PHASE1
NCT02188121 COMPLETED
Serious Mental Illness; Schizophrenia; Schizoaffective Disorder; Bipolar Disorder; Cardiovascular Disease; Major Depressive Disorder; Psychosis NOS
Mclean Hospital
2015-02 PHASE4
NCT05008068 COMPLETED
Platelet-rich Fibrin; Simvastatin
British University In Egypt
2019-08-12 PHASE1
NCT03086291 UNKNOWN
Stomach Cancer
Samsung Medical Center
2018-01-04 PHASE1
NCT02533141 WITHDRAWN
Healthy
Medical University of Vienna
2019-10 PHASE4
NCT00842920 UNKNOWN
Mild Cognitive Impairment
Charite University, Berlin, Germany
2008-12 PHASE4
NCT04836078 COMPLETED
Periodontitis
Assiut University
2020-02-10 EARLY_PHASE1
NCT03452891 COMPLETED
Periodontal Diseases
University of Nebraska
2019-03-01 PHASE4
NCT04559841 COMPLETED
Peri-Implantitis
Reham Lotfy Aggour
2017-10-06
NCT04140201 UNKNOWN
Diabetic Retinopathy
Alaa Hassan ElBaz
2020-02 PHASE4
NCT04374214 UNKNOWN
Reversible Pulpitis
Postgraduate Institute of Dental Sciences Rohtak
2018-12-01
NCT03543774 UNKNOWN
Hypercholesterolemia; Chronic Kidney Diseases
Hue University of Medicine and Pharmacy
2018-06-15 PHASE4
NCT04149080 UNKNOWN
Alveolar Socket Preservation; Bone Regeneration
Universidade Federal Fluminense
2017-11-01
NCT03653663 UNKNOWN
Statin Adverse Reaction; Skeletal Myopathy
Hartford Hospital
2018-01-01 PHASE4
NCT03510715 COMPLETED
Hypercholesterolemia
Sanofi
2018-08-31 PHASE3
NCT03599609 UNKNOWN
Sickle Cell Disease; Stroke
University of Campinas, Brazil
2018-03-05 PHASE1; PHASE2
NCT04406883 COMPLETED
Pain
Islamic Azad University, Sanandaj
2019-04-12 PHASE2
NCT01999309 COMPLETED
Schizophrenia; Schizoaffective Disorder; Schizophreniform Disorder; Psychosis NOS
Iris Sommer
2013-10 PHASE3
NCT02787590 COMPLETED
Parkinson Disease
University Hospital Plymouth NHS Trust
2016-03-08 PHASE2
NCT02743364 COMPLETED
Acute Pancreatitis
National Cancer Institute (NCI)
2016-09-19 PHASE2
NCT03355027 UNKNOWN
Atherosclerosis; Cardiovascular Diseases
Cambridge University Hospitals NHS Foundation Trust
2017-11-30
NCT02390843 COMPLETED
Retinoblastoma; Clear Cell Sarcoma; Renal Cell Carcinoma; Rhabdoid Tumor; Wilms Tumor; Hepatoblastoma; Neuroblastoma; Germ Cell Tumors; Ewings Sarcoma; Non-rhabdomyosarcoma Soft Tissue Sarcoma; Osteosarcoma; Rhabdomyosarcoma
Emory University
2015-02 PHASE1
NCT03585751 UNKNOWN
Tooth, Deciduous
Cairo University
2018-09
NCT03375580 UNKNOWN
Nonalcoholic Fatty Liver Disease
The First Affiliated Hospital of Guangdong Pharmaceutical University
2017-12-31
NCT04418089 COMPLETED
Breast Cancer; Chemotherapy Effect
Indonesia University
2018-01-15 PHASE2
NCT02476006 COMPLETED
Hypercholesterolemia
Sanofi
2015-06-23 PHASE3
NCT03771053 UNKNOWN
Coronary Heart Disease
Chinese PLA General Hospital
2018-01-01
NCT03192293 UNKNOWN
Breast Cancer
National University Hospital, Singapore
2017-01-20 PHASE2
NCT03011931 COMPLETED
Celiac Disease
Entero Therapeutics
2016-03 EARLY_PHASE1
NCT03247400 COMPLETED
Non-segmental Vitiligo
Nicolaus Copernicus University
2016-12-01 PHASE1; PHASE2
NCT03728101 COMPLETED
Healthy
Korea University Guro Hospital
2018-11-16 PHASE1
NCT04177173 COMPLETED
Arthritis, Rheumatoid
King Edward Medical University
2017-09-01 PHASE4
NCT03801733 COMPLETED
Drug Interaction Potentiation
Akebia Therapeutics
2018-06-17 PHASE1
NCT01106495 COMPLETED
Atherosclerosis
Sun Yat-sen University
2010-05
NCT05682911 COMPLETED
The Main Focus of This Study is to Evaluate the Safety of Zingiber Officinale L. Tablets as Hypolipidemic Agent in Hypertensive Patients
Jinnah Sindh Medical University
2018-01-01 EARLY_PHASE1
NCT02428374 UNKNOWN
Myocardial Fibrosis
Federal University of São Paulo
2015-05 PHASE4
NCT02994485 COMPLETED
Portal Hypertension
Tanta University
2016-10 PHASE4
NCT02360618 UNKNOWN
Bladder Cancer
London Health Sciences Centre
2015-10 PHASE2
NCT03745300 COMPLETED
Chronic Periodontitis Wth Diabetes Mellitus
Government Dental College and Research Institute, Bangalore
2017-03-03 PHASE2; PHASE3
NCT03329118 UNKNOWN
Type 2 Diabetes
Jiangsu HengRui Medicine Co., Ltd.
2017-11-24 PHASE1
NCT01439555 COMPLETED
Alzheimer's Disease
University of Massachusetts, Worcester
2011-11 PHASE2
NCT02285738 COMPLETED
Solid Tumor; Cancer
Case Comprehensive Cancer Center
2014-12-30 EARLY_PHASE1
NCT03174041 COMPLETED
Healthy Participants
Genentech, Inc.
2017-04-18 PHASE1
NCT01952288 COMPLETED
TBI-Traumatic Brain Injury
VA Office of Research and Development
2013-09-16 PHASE4
NCT02766803 UNKNOWN
PCOS, Insulin Resistance
Poznan University of Medical Sciences
2016-05 PHASE4
NCT03419429 COMPLETED
Chronic Periodontitis
Ain Shams University
2016-01 PHASE4
NCT02026583 COMPLETED
Colorectal Cancer
Samsung Medical Center
2013-12 PHASE2
NCT02096588 TERMINATED
Breast Cancer; Stage I Breast Cancer; Stage II Breast Cancer; Stage III Breast Cancer
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
2014-05-20 PHASE2
NCT04575090 COMPLETED
Statin-related Muscle Pain; Muscle Aches; Muscle Weakness; Muscle Cramp; Muscle Stiffness
University of Texas Southwestern Medical Center
2016-03-05
NCT02714569 COMPLETED
Dyslipidemias
Eli Lilly and Company
2016-03 PHASE1
NCT02465645 COMPLETED
Cirrhosis With Esophageal Varices
Institute of Liver and Biliary Sciences, India
2015-06-01
NCT01156545 COMPLETED
Non-small Cell Lung Cancer
National Cancer Center, Korea
2010-10 PHASE2
NCT02255682 COMPLETED
Cardiovascular Disease; Diabetes Mellitus
University of Copenhagen
2015-01 PHASE4
NCT01772719 TERMINATED
Multiple Myeloma
University of Louisville
2012-08
NCT03400475 COMPLETED
Peri-implant Mucositis
Ahmed Mohamed Mahrous
2015-04-23 PHASE2
NCT02548936 UNKNOWN
Atherosclerosis
Peking Union Medical College Hospital
2015-04 EARLY_PHASE1
NCT02015988 UNKNOWN
Acute Coronary Syndrome; Diabetes Mellitus, Type 2; Hypertriglyceridemia
Koval' O., MD
2014-01 PHASE4
NCT01160978 COMPLETED
Heart Failure; Respiratory Failure; Liver Failure; Kidney Failure; Transplantation
Helsinki University Central Hospital
2010-06-01 PHASE2; PHASE3
NCT02360826 COMPLETED
Drug Distribution
Children's Mercy Hospital Kansas City
2014-06-17 PHASE1
NCT02817243 UNKNOWN
Type 2 Diabetes
Jiangsu HengRui Medicine Co., Ltd.
2016-03 PHASE1
NCT00656292 COMPLETED
Perioperative Inflammatory Response
Mayo Clinic
2008-04 PHASE4
NCT02017639 COMPLETED
Rheumatoid Arthritis
Sanofi
2014-01 PHASE1
NCT02675309 COMPLETED
Healthy
Tanabe Pharma Corporation
2016-02 PHASE1
NCT02685462 COMPLETED
Healthy
Tobira Therapeutics, Inc.
2016-01-31 PHASE1
NCT04803500 COMPLETED
Immediate Implant Placement; Bone Regeneration; Alveolar Bone Resorption
Ain Shams University
2015-04-02 PHASE2
NCT04183387 COMPLETED
Uveitis
Federal State Budgetary Scientific Institution, Research Institute of Fundamental and Clinical Immunology
2014-09 PHASE2
NCT02886299 COMPLETED
Fenofibrate/Simvastatin Comparison
Cairo University
2013-10 PHASE4
NCT02547402 COMPLETED
Acute Kidney Injury
Complexa, Inc.
2015-12 PHASE1
NCT02030041 COMPLETED
Dyslipidemias
Post Graduate Institute of Medical Education and Research, Chandigarh
2013-12 PHASE3
NCT02104193 COMPLETED
Brain Metastases
Ain Shams University
2014-04 PHASE2
NCT02399709 COMPLETED
Smoking Cessation
Poitiers University Hospital
2015-04-01 PHASE2
NCT01142336 COMPLETED
Alzheimer's Disease
University of Washington
2010-06 PHASE4
NCT02542969 COMPLETED
Healthy
Madrigal Pharmaceuticals, Inc.
2015-09 PHASE1
NCT02406261 COMPLETED
Healthy
AstraZeneca
2015-04-30 PHASE1
NCT02431013 UNKNOWN
Dyslipidemias; Peripheral Artery Disease
Ajou University School of Medicine
2015-04 PHASE1
NCT02072382 UNKNOWN
Hypertension
Hospital de Clinicas de Porto Alegre
2013-05 PHASE4
NCT01771198 TERMINATED
Rhinosinusitis
Centre hospitalier de l'Université de Montréal (CHUM)
2012-08 PHASE2
NCT02447601 COMPLETED
Type 2 Diabetes Mellitus
Jiangsu Hansoh Pharmaceutical Co., Ltd.
2015-03-30 PHASE1
NCT01702246 COMPLETED
Sickle Cell Disease
UCSF Benioff Children's Hospital Oakland
2012-02 PHASE1; PHASE2
NCT02256254 COMPLETED
Oxidative Stress
Rigshospitalet, Denmark
2014-09 PHASE2
NCT01225263 COMPLETED
Migraine
Rami Burstein
2010-09 PHASE2
NCT01520077 COMPLETED
Alopecia Areata
University of Miami
2011-07 PHASE1
NCT00807950 UNKNOWN
Breast Cancer
National University Hospital, Singapore
2008-03 PHASE2
NCT01382511 UNKNOWN
Pachyonychia Congenita
Tel-Aviv Sourasky Medical Center
2011-07
NCT01420549 COMPLETED
Hypercholesterolemia; Dyslipidemia
Ache Laboratorios Farmaceuticos S.A.
2013-03 PHASE3
NCT03402204 COMPLETED
Ischemic Stroke
Thammasat University
2014-04-01 PHASE3
NCT01665950 TERMINATED
Bipolar Disorder
Massachusetts General Hospital
2012-08 PHASE2
NCT01434745 TERMINATED
Smith-Lemli-Opitz Syndrome
Oregon Health and Science University
2011-09
NCT02367937 COMPLETED
Healthy
Pronova BioPharma
2014-08 PHASE1
NCT00202878 COMPLETED
Hypercholesterolemia; Myocardial Infarction
Organon and Co
2005-10-17 PHASE3
NCT01944176 COMPLETED
COPD
Mahidol University
2013-09 PHASE3
NCT02372656 COMPLETED
Chronic Periodontitis
Government Dental College and Research Institute, Bangalore
2013-12 PHASE2; PHASE3
NCT01097785 COMPLETED
Heart Failure
University of Missouri-Columbia
2009-03
NCT01561482 WITHDRAWN
Prostate Carcinoma
Nicholas Mitsiades
2012-01 PHASE2
NCT01587235 WITHDRAWN
Dyslipidemia
Organon and Co
2013-03 PHASE4
NCT02815722 COMPLETED
Type 2 Diabetes
Jiangsu HengRui Medicine Co., Ltd.
2013-07 PHASE1
NCT01709500 COMPLETED
Heterozygous Familial Hypercholesterolemia
Regeneron Pharmaceuticals
2012-12 PHASE3
NCT01321255 COMPLETED
Myocardial Infarction
Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III
2012-01 PHASE3
NCT02134626 COMPLETED
Portal Hypertension; Esophageal Varices; Liver Cirrhosis
Universidade Federal do Rio de Janeiro
2010-08 PHASE3
NCT01282385 UNKNOWN
Liver Cirrhosis; Portal Hypertension.
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
2011-04 PHASE4
NCT01953835 COMPLETED
Systemic Lupus Erythematosus
GlaxoSmithKline
2013-10-04 PHASE1
NCT01978327 TERMINATED
Alzheimer's Disease
GlaxoSmithKline
2013-11-22 PHASE1
NCT02120872 COMPLETED
Three Wall Intrabony Defects in Chronic Periodontitis
Government Dental College and Research Institute, Bangalore
2013-02 PHASE2
NCT02129231 COMPLETED
Oxidative Stress; Diabetic Polyneuropathy
University of Guadalajara
2012-02 PHASE2
NCT01061671 TERMINATED
Pulmonary Disease, Chronic Obstructive
University of Minnesota
2010-03 PHASE3
NCT05072405 COMPLETED
Drug Interaction
Chinese University of Hong Kong
2013-01-11 PHASE4
NCT01960140 COMPLETED
Healthy Volunteers
Eli Lilly and Company
2013-10 PHASE1
NCT01517893 COMPLETED
Vitiligo
John Harris
2012-01 PHASE2
NCT01763866 COMPLETED
Hyperlipidemia
Amgen
2013-01-15 PHASE3
NCT01678820 TERMINATED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2012-10-10 PHASE3
NCT01238094 UNKNOWN
Colorectal Cancer
Samsung Medical Center
2010-04 PHASE3
NCT01857843 COMPLETED
Acute Coronary Syndrome
Yonsei University
2009-11 PHASE4
NCT02060032 COMPLETED
Chronic Periodontitis
Government Dental College and Research Institute, Bangalore
2013-02 PHASE2; PHASE3
NCT01674712 COMPLETED
Dyslipidemia
Abbott
2012-06 PHASE3
NCT00995670 COMPLETED
Hyperglycemia
US Department of Veterans Affairs
2010-03
NCT00994903 COMPLETED
Intestinal Neoplasm; Perioperative Care
University of Auckland, New Zealand
2011-10 PHASE3
NCT01205347 COMPLETED
Myocardial Infarction
Brasilia Heart Study Group
2010-10 PHASE4
NCT01095185 COMPLETED
Cirrhosis; Hypertension, Portal; Bleeding Esophageal Varices; Portal Vein Thrombosis
Juan A. Arnaiz
2010-11 PHASE3
NCT00939822 COMPLETED
Alzheimer's Disease
University of Wisconsin, Madison
2009-03 PHASE2
NCT01870466 COMPLETED
Healthy
Samsung Medical Center
2012-06 PHASE1
NCT01923077 UNKNOWN
Acute Myocardial Infarction
Svendborg Hospital
2010-04 PHASE2
NCT00731627 COMPLETED
Subarachnoid Haemorrhage
Cambridge University Hospitals NHS Foundation Trust
2007-01 PHASE3
NCT00944463 COMPLETED
Pancreatic Cancer
Samsung Medical Center
2008-10 PHASE2
NCT01686451 COMPLETED
Dyslipidemias
Wenzhou Medical University
2012-08 PHASE4
NCT01651728 UNKNOWN
Community-Acquired Pneumonia
Indonesia University
2012-07 PHASE3
NCT01654562 TERMINATED
Choroideremia
University of Alberta
2012-12 PHASE1; PHASE2
NCT00879710 COMPLETED
Type 1 Diabetes Mellitus; Type 2 Diabetes Mellitus; Hypercholesterolemia
Medical College of Wisconsin
2008-08
NCT01077206 COMPLETED
Subarachnoid Hemorrhage
Chinese University of Hong Kong
2010-09 PHASE2; PHASE3
NCT01602029 COMPLETED
Schizophrenia; Schizoaffective Disorder; Psychosis Not Otherwise Specified; Schizophreniform Disorder
Pakistan Institute of Living and Learning
2010-08 PHASE2
NCT01099085 COMPLETED
Gastric Cancer
Samsung Medical Center
2009-02 PHASE3
NCT01702298 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2012-12-07 PHASE3
NCT01179464 COMPLETED
Bone Metastases of a Malignant Tumor
Amsterdam UMC, location VUmc
2010-08
NCT00572468 COMPLETED
Cancer; Prostate Cancer
VA Office of Research and Development
2007-12
NCT02070133 COMPLETED
Chronic Obstructive Pulmonary Disease
Hospital Universitari Son Dureta
2009-05 PHASE3
NCT00795288 COMPLETED
Subarachnoid Hemorrhage
Washington University School of Medicine
2008-08 PHASE1; PHASE2
NCT01725230 COMPLETED
Rheumatoid Arthritis
AstraZeneca
2012-11 PHASE1
NCT01057758 TERMINATED
Pneumonia
Assistance Publique Hopitaux De Marseille
2009-09 PHASE3
NCT00321802 COMPLETED
Atrial Fibrillation
University of Calgary
2006-04 PHASE2
NCT01500577 COMPLETED
Breast Cancer
European Institute of Oncology
2005-04 PHASE2
NCT01666067 COMPLETED
Hypercholesterolemia
Gachon University Gil Medical Center
2011-11 PHASE4
NCT01101204 UNKNOWN
Diabetes; Dyslipidemia; Inflammation; Cytokines
Medical University of Silesia
2012-07
NCT00461630 COMPLETED
Cardiovascular Disease; Peripheral Arterial Disease; Diabetes Mellitus; Coronary Heart Disease
University of Oxford
2007-01 PHASE3
NCT00926055 WITHDRAWN
Atherosclerosis
Korea University
2011-09
NCT00120289 TERMINATED
Cardiovascular Diseases; Heart Diseases; Cerebrovascular Accident; Coronary Disease; Atherosclerosis; Myocardial Infarction
Axio Research. LLC
2005-09 PHASE3
NCT01281761 COMPLETED
Metastatic Colorectal Cancer
Samsung Medical Center
2010-11 PHASE2
NCT01011660 UNKNOWN
Essential Hypertension
Chinese Academy of Medical Sciences, Fuwai Hospital
2007-10 PHASE4
NCT01689623 COMPLETED
Healthy Participants
Janssen Research & Development, LLC
2012-06 PHASE1
NCT01487460 COMPLETED
Dyslipidemia; Healthy Volunteers
Novartis Pharmaceuticals
2011-11 PHASE1
NCT00984750 COMPLETED
Diabetes Type 2; Hypertension
Mario Negri Institute for Pharmacological Research
2008-04 PHASE3
NCT01362218 TERMINATED
Elevated LDL Cholesterol
Ferrer Internacional S.A.
2010-10 PHASE2
NCT01282398 UNKNOWN
Portal Hypertension.; Liver Cirrhosis
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
2011-04 PHASE4
NCT01342211 COMPLETED
Hypercholesterolemia; Dyslipidemia
Pfizer
2011-07 PHASE2
NCT01294683 TERMINATED
Primary Hypercholesterolemia; Dyslipidemia
Merck Sharp & Dohme LLC
2011-02-04 PHASE3
NCT01335997 TERMINATED
Primary Hypercholesterolemia; Mixed Dyslipidemia
Merck Sharp & Dohme LLC
2011-05-01 PHASE3
NCT00575965 TERMINATED
Waldenstrom's Macroglobulinemia
Dana-Farber Cancer Institute
2007-11 PHASE2
NCT01469468 COMPLETED
Type 2 Diabetes Mellitus
Pfizer
2011-11 PHASE1
NCT00508027 COMPLETED
Sickle Cell Disease
UCSF Benioff Children's Hospital Oakland
2007-06 PHASE1; PHASE2
NCT02304926 COMPLETED
Dyslipidemia
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
2009-01
NCT00647348 COMPLETED
Secondary Progressive Multiple Sclerosis
Imperial College London
2008-01 PHASE2
NCT00819403 COMPLETED
Metabolic Syndrome
University of Maryland, Baltimore
2009-01 PHASE4
NCT00994773 COMPLETED
Hepatitis B
Bader, Ted, M.D.
2009-12 PHASE1
NCT01195428 WITHDRAWN
Adult Respiratory Distress Syndrome; Acute Lung Injury
University of Oklahoma
2010-10
NCT00528580 TERMINATED
Sepsis
University of Chicago
2008-02 PHASE2
NCT01383395 COMPLETED
Healthy
Samsung Medical Center
2011-06 PHASE1
NCT01445860 COMPLETED
Human Volunteers
Pfizer
2011-08 PHASE1
NCT01047423 WITHDRAWN
Hypertension
Queen's University, Belfast
2009-08 PHASE4
NCT00605995 TERMINATED
Schizophrenia
New York State Psychiatric Institute
2008-02
NCT00990834 WITHDRAWN
Hydroxymethylglutaryl-CoA Reductase Inhibitors; Myopathy
Scripps Health
2009-11
NCT01338324 COMPLETED
Celiac Disease
All India Institute of Medical Sciences
2010-04 PHASE2; PHASE3
NCT01105975 COMPLETED
Dyslipidemia
Eli Lilly and Company
2010-04 PHASE2
NCT00761904 UNKNOWN
Hypertension; Hyperlipidemia
Brigham and Women's Hospital
2010-12
NCT01304329 COMPLETED
Healthy
Boehringer Ingelheim
2011-02 PHASE1
NCT00831129 COMPLETED
Pre-diabetes
University of Chicago
2006-09 PHASE2; PHASE3
NCT00862251 COMPLETED
Cardiovascular Disorder; Diabetes Mellitus
Organon and Co
2009-04 PHASE3
NCT01004705 TERMINATED
Elevated LDL Cholesterol
Ferrer Internacional S.A.
2009-09 PHASE2
NCT00680641 UNKNOWN
COPD; Emphysema
University of East Anglia
2008-04 PHASE4
NCT00452244 COMPLETED
Lung Cancer
National Cancer Center, Korea
2006-05 PHASE2
NCT02305355 COMPLETED
Diabetes Mellitus, Type 2; Hypertriglycemia
Kuhnil Pharmaceutical Co., Ltd.
2009-02 PHASE4
NCT00828282 COMPLETED
Chronic Lymphocytic Leukemia
John Haslip
2009-03 PHASE1
NCT00664846 COMPLETED
Stroke
Peking Union Medical College Hospital
2008-04
NCT00064792 COMPLETED
Smith-Lemli-Opitz Syndrome
Forbes Porter, M.D.
2003-07 PHASE2
NCT00676897 COMPLETED
Septic Shock
Beth Israel Deaconess Medical Center
2008-02 PHASE2; PHASE3
NCT01290380 TERMINATED
Solid Tumor Malignancies
Novartis Pharmaceuticals
2010-02 PHASE1
NCT01085149 UNKNOWN
Hypercholesterolemia
Hadassah Medical Organization
2010-05
NCT00804843 COMPLETED
Carotid Atherosclerosis
Merck Sharp & Dohme LLC
2009-04 PHASE2
NCT01005290 TERMINATED
Hypertension
Ferrer Internacional S.A.
2009-10 PHASE2
NCT00817843 COMPLETED
Metabolic Syndrome
dr.Frank L.J. Visseren
2009-04 PHASE4
NCT01147692 COMPLETED
Diabetes Mellitus, Type 2
GlaxoSmithKline
2010-05-19 PHASE1
NCT00289900 COMPLETED
Mixed Hyperlipidemia
Merck Sharp & Dohme LLC
2006-01-24 PHASE3
NCT00125593 COMPLETED
Kidney Disease, Chronic
University of Oxford
2003-06 PHASE4
NCT01096940 COMPLETED
Type 2 Diabetes Mellitus
AstraZeneca
2010-03 PHASE1
NCT00738972 TERMINATED
Hypertension
Fundación Lindavista del Corazón AC
2008-01 PHASE3
NCT01138072 COMPLETED
Infection, Human Immunodeficiency Virus
GlaxoSmithKline
2010-06 PHASE1
NCT00477204 COMPLETED
Type 1 Diabetes Mellitus; Dyslipidemia
University of Colorado, Denver
2007-05 PHASE2
NCT01092572 WITHDRAWN
Cystic Fibrosis; Systemic Inflammation
University of British Columbia
2010-05 PHASE1; PHASE2
NCT01384058 COMPLETED
Diabetes Mellitus Type 2; Hypercholesterolemia
University Hospital Freiburg
2007-11 PHASE4
NCT01103739 COMPLETED
Chronic Pain
Pfizer
2010-03 PHASE1
NCT00743197 TERMINATED
Chest Pain
Northwestern University
2008-05
NCT00932620 COMPLETED
Hypercholesterolemia
University of Ioannina
2009-06 PHASE4
NCT00492765 COMPLETED
Multiple Sclerosis
Biogen
2006-02 PHASE4
NCT00664469 TERMINATED
Hypercholesterolemia
Sunnybrook Health Sciences Centre
2007-08 PHASE3
NCT01299597 COMPLETED
Sleep Disorders
GlaxoSmithKline
2010-01-18 PHASE1
NCT00261326 UNKNOWN
Optic Neuritis; Multiple Sclerosis
Glostrup University Hospital, Copenhagen
2006-09 PHASE3
NCT00481351 COMPLETED
Coronary Heart Disease
University of Sao Paulo
2007-06 PHASE4
NCT00905905 COMPLETED
Myocardial Infarction
Brasilia Heart Study Group
2009-05 PHASE4
NCT00542178 COMPLETED
Diabetic Retinopathy
National Heart, Lung, and Blood Institute (NHLBI)
2003-10 PHASE3
NCT00452634 COMPLETED
Small Cell Lung Cancer
National Cancer Center, Korea
2006-04 PHASE2
NCT00587678 COMPLETED
Peripheral Artery Disease
University of Virginia
2006-01
NCT00384865 TERMINATED
Hypertension, Pulmonary
University of Pennsylvania
2006-09 PHASE2
NCT00699023 COMPLETED
Postprandial Lipemia; Type 2 Diabetes
Federico II University
2008-06 PHASE4
NCT00718796 COMPLETED
Cardiovascular Disease
The Canadian College of Naturopathic Medicine
2008-04 PHASE3
NCT00704548 UNKNOWN
Hypertension
Hospital de Clinicas de Porto Alegre
2008-06 PHASE4
NCT00929955 COMPLETED
Schizophrenia; Schizoaffective Disorder; Psychosis Not Otherwise Specified; Schizophreniform Disorder
Pakistan Institute of Living and Learning
2009-06 PHASE1
NCT00802100 COMPLETED
Schizophrenia
National Institute of Mental Health (NIMH)
2008-12 PHASE4
NCT00792337 COMPLETED
Asthma
Mahidol University
2008-12 PHASE3
NCT00678743 COMPLETED
Dyslipidemias
Provident Clinical Research
2007-08 PHASE4
NCT00973115 COMPLETED
Hyperlipidemia
Hanmi Pharmaceutical Company Limited
2007-11 PHASE3
NCT00987558 COMPLETED
Epilepsy
Bial - Portela C S.A.
2009-06 PHASE1
NCT00654628 COMPLETED
Hypercholesterolemia
Organon and Co
2007-08-01 PHASE4
NCT00924430 COMPLETED
Type 2 Diabetes Mellitus
Solvay Pharmaceuticals
2009-06 PHASE1
NCT01061450 COMPLETED
Diastolic Dysfunction; Hypertension
Brasilia Heart Study Group
2006-11 PHASE4
NCT00861731 UNKNOWN
Hypercholesterolemia; Chronic Nephropathy
Azienda Ospedaliero Universitaria di Sassari
2008-11 PHASE4
NCT00404599 UNKNOWN
Diabetes Mellitus; Hypertension
Amsterdam UMC, location VUmc
2007-02 PHASE4
NCT00653523 COMPLETED
Hypercholesterolemia
Organon and Co
2007-12-01 PHASE3
NCT00000620 COMPLETED
Atherosclerosis; Cardiovascular Diseases; Hypercholesterolemia; Hypertension; Diabetes Mellitus, Type 2; Diabetes Mellitus; Coronary Disease
National Heart, Lung, and Blood Institute (NHLBI)
1999-09 PHASE3
NCT00334542 COMPLETED
Breast Cancer
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
2006-03 PHASE2
NCT00812955 COMPLETED
Dyslipidemia, Hypercholesterolemia, Hypertriglyceridemia
AstraZeneca
2008-11 PHASE3
NCT00725829 UNKNOWN
Acute Coronary Syndrome
Jagiellonian University
2008-06
NCT00718328 TERMINATED
Intracerebral Hemorrhage
Johns Hopkins University
2008-10 PHASE2
NCT00906451 COMPLETED
Myocardial Infarction; Inflammation; Endothelial Dysfunction
Brasilia Heart Study Group
2008-11 PHASE4
NCT00762164 COMPLETED
Hypercholesterolemia
Bronx VA Medical Center
2007-03 PHASE4
NCT00734123 UNKNOWN
Atherosclerosis; Cardiovascular Diseases
Hospital Arnau de Vilanova
2008-04 PHASE4
NCT00839683 COMPLETED
Type 2 Diabetes Mellitus
AstraZeneca
2009-02 PHASE1
NCT01021579 COMPLETED
Polycystic Ovary Syndrome
Fasa University of Medical Sciences
2008-01 PHASE4
NCT00503763 WITHDRAWN
Smoldering Multiple Myeloma
Meir Medical Center
2007-09 PHASE2
NCT00655993 COMPLETED
COPD; Inflammation
VA Loma Linda Health Care System
2008-04 PHASE1
NCT00535405 COMPLETED
Hypercholesterolemia
Organon and Co
2007-11 PHASE3
NCT00531882 COMPLETED
Cystic Fibrosis
University Hospitals Cleveland Medical Center
2007-09
NCT00487461 TERMINATED
Aneurysmal Subarachnoid Hemorrhage; Cerebral Vasospasm
University of Illinois at Chicago
2007-05
NCT00474123 COMPLETED
Stable Angina
University of Sao Paulo
2006-01
NCT00208117 TERMINATED
Depression; Coronary Artery Disease (CAD); Acute Coronary Syndrome (ACS)
New York State Psychiatric Institute
2005-04 PHASE1
NCT00491530 COMPLETED
Mixed Dyslipidemia
Abbott
2007-06 PHASE3
NCT00354640 COMPLETED
Breast Cancer
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
2006-06 PHASE2
NCT00180713 COMPLETED
Pulmonary Hypertension
Imperial College London
2005-10 PHASE1; PHASE2
NCT00442897 COMPLETED
Hypercholesterolemia
Organon and Co
2006-09 PHASE4
NCT00443794 COMPLETED
Cardiovascular Diseases
St. John's Research Institute
2007-03
NCT00349375 COMPLETED
Hyperlipidemia
Solvay Pharmaceuticals
2005-11 PHASE3
NCT00525824 COMPLETED
Hypercholesterolemia; Coronary Heart Disease; Atherosclerosis
AstraZeneca
2007-08 PHASE3
NCT01821027 COMPLETED
Healthy
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
2008-08 PHASE1
NCT00736606 COMPLETED
Healthy Volunteers
AstraZeneca
2008-08 PHASE1
NCT00362206 COMPLETED
Hyperlipidemia
Solvay Pharmaceuticals
2006-09 PHASE3
NCT00496730 COMPLETED
Hypercholesterolemia
Organon and Co
2007-07 PHASE3
NCT00362934 COMPLETED
Hyperlipidemia
Solvay Pharmaceuticals
2006-10 PHASE3
NCT00716846 COMPLETED
Healthy Volunteers
Hamamatsu University
2006-06
NCT00947323 COMPLETED
Erectile Dysfunction; Vascular Disease Detected; C Reactive Protein
Santa Casa de Porto Alegre
2006-01 PHASE3
NCT00479388 COMPLETED
Primary Hypercholesterolemia; Mixed Dyslipidemia
Merck Sharp & Dohme LLC
2007-07 PHASE3
NCT00769210 COMPLETED
Heart Failure
University of Utah
2005-05 EARLY_PHASE1
NCT00903409 COMPLETED
Hypertriglyceridemia
GlaxoSmithKline
2005-11-15 PHASE3
NCT00479882 COMPLETED
Primary Hypercholesterolemia; Mixed Dyslipidemia
Merck Sharp & Dohme LLC
2007-06-15 PHASE3
NCT00462748 COMPLETED
Hypercholesterolemia
Organon and Co
2007-03 PHASE3
NCT00124072 COMPLETED
Cardiovascular Disease
University of Oxford
1998-07 PHASE3
NCT00693576 COMPLETED
Renal Transplantation
Shiraz University of Medical Sciences
2007-04 PHASE2; PHASE3
NCT00753883 COMPLETED
Hyperlipidemia
Merck Sharp & Dohme LLC
2006-07 PHASE4
NCT00092677 COMPLETED
Aortic Stenosis
Organon and Co
2001-01 PHASE3
NCT00669435 UNKNOWN
Hypertension
University of Pavia
2008-04 PHASE4
NCT00423579 COMPLETED
Hypercholesterolemia; Coronary Disease
Organon and Co
2006-07-01 PHASE4
NCT00479713 COMPLETED
Hypercholesterolemia
Organon and Co
2007-02-01 PHASE3
NCT00300430 COMPLETED
Dyslipidemia; Coronary Heart Disease; Mixed Dyslipidemia
Abbott
2006-09 PHASE3
NCT00605449 COMPLETED
Type 2 Diabetes Mellitus
GlaxoSmithKline
2008-01 PHASE1
NCT00668343 COMPLETED
Relapsing Remitting Multiple Sclerosis
Tehran University of Medical Sciences
2005-04 PHASE3
NCT00255242 COMPLETED
Cystic Fibrosis
Akron Children's Hospital
2004-07 PHASE1
NCT00271817 COMPLETED
Hypercholesterolemia
Organon and Co
2005-12 PHASE3
NCT00988364 COMPLETED
Metabolic Syndrome
Baylor College of Medicine
2007-03 PHASE4
NCT00465088 COMPLETED
Hyperlipidemia; Mixed Dyslipidemia
Abbott
2007-04 PHASE3
NCT00560170 COMPLETED
Atherosclerosis
National Cheng-Kung University Hospital
2007-09 PHASE4
NCT00359281 COMPLETED
Healthy
Aegerion Pharmaceuticals, Inc.
2006-03 PHASE2
NCT00053599 COMPLETED
Alzheimer Disease
National Institute on Aging (NIA)
2002-12 PHASE3
NCT00166504 COMPLETED
Hypercholesterolemia
Organon and Co
2005-10 PHASE4
NCT00504439 COMPLETED
Pulmonary Disease, Chronic Obstructive
GlaxoSmithKline
2007-06-04 PHASE1
NCT00157924 COMPLETED
Hypercholesterolemia
Organon and Co
2005-11 PHASE4
NCT00943124 COMPLETED
Dyslipidemia
Merck Sharp & Dohme LLC
2007-07 PHASE1
NCT00344175 COMPLETED
Hypercholesterolemia; Dyslipidemia; Coronary Heart Disease
Kowa Research Europe
2006-06 PHASE3
NCT00316095 COMPLETED
Hypertension; Dyslipidemias
Boehringer Ingelheim
2006-04 PHASE3
NCT00506961 COMPLETED
Diabetes Mellitus; Dyslipidemia
Taipei Veterans General Hospital, Taiwan
2006-06 PHASE4
NCT00652431 COMPLETED
Hypercholesterolemia; Hyperlipidemia
Organon and Co
2007-05 PHASE1
NCT00652327 COMPLETED
Hypercholesterolemia
Organon and Co
2005-12 PHASE4
NCT00720577 COMPLETED
Peripheral Arterial Disease
Medtronic Endovascular
2005-12 EARLY_PHASE1
NCT00132717 COMPLETED
Hypercholesterolemia
Organon and Co
2005-01-01 PHASE3
NCT00395603 TERMINATED
Cardiovascular Diseases; Diabetes Mellitus
Organon and Co
2006-09 PHASE3
NCT00129402 COMPLETED
Hypercholesterolemia
Organon and Co
2005-08 PHASE3
NCT00286481 COMPLETED
Hypercholesterolemia
Takeda
2006-03 PHASE3
NCT00594191 COMPLETED
Cirrhosis; Portal Hypertension
Hospital Clinic of Barcelona
2004-03 PHASE2
NCT00114504 COMPLETED
Atherosclerosis
Kurume University
2004-09
NCT00377442 COMPLETED
Diabetes Mellitus Type 2
Hoffmann-La Roche
2006-08 PHASE1
NCT00300456 COMPLETED
Dyslipidemia; Coronary Heart Disease; Mixed Dyslipidemia
Abbott
2006-03 PHASE3
NCT00385658 COMPLETED
Dyslipidemia
Novartis
2006-08 PHASE4
NCT00256178 COMPLETED
Hypercholesterolemia
Takeda
2005-10 PHASE3
NCT00423488 COMPLETED
Hypercholesterolemia; Diabetes Mellitus, Type 2; Coronary Disease
Organon and Co
2005-07-12 PHASE3
NCT00166530 COMPLETED
Atherosclerosis
Organon and Co
2005-11 PHASE4
NCT02511418 COMPLETED
Hyperlipidemia; Hypertension; Chronic Renal Failure
Mayo Clinic
NCT00269217 COMPLETED
Primary Hypercholesterolemia; Mixed Hyperlipidemia
Merck Sharp & Dohme LLC
2006-01 PHASE3
NCT00267280 TERMINATED
Hyperlipidemia; Dyslipidemia; Hypercholesterolemia
Pfizer
2006-01 PHASE3
NCT00413972 COMPLETED
Hypercholesterolemia
Organon and Co
2006-04 PHASE3
NCT00309777 COMPLETED
Hypercholesterolemia; Dyslipidemia
Kowa Research Europe
2005-09 PHASE3
NCT00254475 COMPLETED
Essential Hypertension; Hypercholesterolemia
Novartis
2005-11 PHASE3
NCT01424891 COMPLETED
Type 2 Diabetes; Inflammation
Heidelberg University
2004-04
NCT00246701 COMPLETED
Hypertriglyceridemia
GlaxoSmithKline
2005-11-01 PHASE3
NCT00651014 TERMINATED
Hypercholesterolemia; Atherosclerosis
Organon and Co
2004-01 PHASE4
NCT01103648 COMPLETED
Prediabetes; Hypercholesterolemia; Inflammation; Cardiovascular Risk
Federal University of São Paulo
2005-06
NCT00398294 COMPLETED
Hypercholesterolemia
Organon and Co
2005-05-01 PHASE4
NCT00587717 COMPLETED
Carotid Artery Disease
Mayo Clinic
2002-09
NCT00235963 COMPLETED
Subarachnoid Hemorrhage; Delayed Vasospasm
Brigham and Women's Hospital
2002-12 PHASE1; PHASE2
NCT00397826 COMPLETED
Hypercholesterolemia
Cardinal Tien Hospital
2005-01 PHASE4
NCT00171093 COMPLETED
HYPERTENSION; HYPERCHOLESTEROLEMIA
Novartis
2004-09 PHASE3
NCT00651560 COMPLETED
Hyperlipidemia
Organon and Co
2005-11-01 PHASE3
NCT00738296 COMPLETED
Cardiovascular Diseases
Hospital Universitario 12 de Octubre
2005-04 PHASE4
NCT00110435 COMPLETED
Type 2 Diabetes Mellitus; Hypercholesterolemia
Organon and Co
2005-05 PHASE3
NCT02183623 COMPLETED
Healthy
Boehringer Ingelheim
2005-09 PHASE1
NCT00541697 COMPLETED
Diabetes Mellitus, Type 2
Organon and Co
2005-01-19 PHASE3
NCT00093899 COMPLETED
Hyperlipidemia; Hypercholesterolemia; Hypertriglyceridemia
Organon and Co
2004-11 PHASE3
NCT00704314 COMPLETED
Hypercholesterolemia; Diabetes; Cardiovascular Disease
Medical University of Vienna
2002-10
NCT01167933 COMPLETED
Healthy
Dr. Reddy's Laboratories Limited
2005-01 PHASE1
NCT01167894 COMPLETED
Healthy
Dr. Reddy's Laboratories Limited
2005-01 PHASE1
NCT00303277 COMPLETED
Alzheimer's Disease; Aging
Seattle Institute for Biomedical and Clinical Research
2002-08 PHASE4
NCT00652717 COMPLETED
Cardiovascular Disorder
Organon and Co
2005-02-01 PHASE4
NCT00650819 COMPLETED
Hypercholesterolemia
Organon and Co
2004-06-01 PHASE3
NCT00090298 COMPLETED
Hypercholesterolemia
Organon and Co
2004-04 PHASE3
NCT00688558 COMPLETED
Dyslipidemia
Akros Pharma Inc.
2004-02 PHASE2
NCT00090168 COMPLETED
Hypercholesterolemia; Atherosclerotic Disease; Coronary Disease
Organon and Co
2004-01-27 PHASE3
NCT00451828 COMPLETED
Hyperlipidemia; Hypercholesterolemia; Coronary Heart Disease; Cardiovascular Disease
UCSF Benioff Children's Hospital Oakland
2002-03 PHASE4
NCT00650663 COMPLETED
Hypercholesterolemia; Atherosclerosis
Organon and Co
2003-10-01 PHASE4
NCT00651391 TERMINATED
Hypercholesterolemia; Atherosclerosis
Organon and Co
2003-10-01 PHASE3
NCT00653835 COMPLETED
Hypercholesterolaemia; Atherosclerosis
Organon and Co
2003-09-01 PHASE4
NCT00651274 COMPLETED
Atherosclerosis; Hypercholesterolemia; Coronary Heart Disease
Organon and Co
2003-04-01 PHASE4
NCT00652444 COMPLETED
Hypercholesterolemia
Organon and Co
2003-09 PHASE4
NCT00317993 COMPLETED
Healthy Men
University of Cologne
2004-04 PHASE4
NCT00092599 COMPLETED
Hypercholesterolemia; Coronary Disease
Organon and Co
2003-02 PHASE3
NCT00092612 COMPLETED
Hypercholesterolemia; Coronary Disease
Organon and Co
2003-05 PHASE3
NCT00652301 COMPLETED
Cholesterol
Organon and Co
2003-07 PHASE3
NCT00251576 COMPLETED
Acute Coronary Syndrome
Organon and Co
1999-11-01 PHASE3
NCT00330980 COMPLETED
Dyslipidemias
University of California, San Diego
2000-04 PHASE4
NCT00157911 COMPLETED
Hypercholerolemia
Organon and Co
2002-12 PHASE3
NCT00092664 COMPLETED
Hypercholesterolemia
Organon and Co
2003-01 PHASE3
NCT00092651 COMPLETED
Hypercholesterolemia
Organon and Co
2002-09 PHASE3
NCT00753779 COMPLETED
Hypercholesterolemia
Daiichi Sankyo
2002-11 PHASE4
NCT00385931 COMPLETED
Hypertension; Hypercholesterolemia; Dyslipidemia
Novartis
2002-01 PHASE3
NCT00092157 COMPLETED
Hypercholesterolemia
Organon and Co
2002-05-01 PHASE3
NCT00551447 COMPLETED
Coronary Disease
Organon and Co
2002-01 PHASE3
NCT00389896 COMPLETED
HDL Cholesterol
Organon and Co
2001-07-26 PHASE3
NCT03884452 COMPLETED
Familial Hypercholesterolemia
Organon and Co
2000-05-03 PHASE3
NCT02587390 COMPLETED
Hypercholesterolemia
NeuroBo Pharmaceuticals Inc.
2000-05 PHASE1
NCT02187536 COMPLETED
Healthy
Boehringer Ingelheim
2000-04 PHASE1
NCT00004266 COMPLETED
Diabetic Nephropathy
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
1993-08 PHASE3
NCT00905541 COMPLETED
Hypercholesterolemia
University Hospital, Bonn
1998-11
NCT00309712 COMPLETED
Type II Diabetes Mellitus; Mixed Dyslipidemia
Intermountain Health Care, Inc.
2002-08
NCT00538044 UNKNOWN
Hypertension, Pulmonary
Capital Medical University
2009-01 PHASE1
NCT00654446 COMPLETED
Fredrickson Type IIa & Type IIb Dyslipidaemia
AstraZeneca
2002-09 PHASE3
NCT00157482 COMPLETED
Type 2 Diabetes
Mario Negri Institute for Pharmacological Research
2005-01 PHASE2
NCT00654537 COMPLETED
Hypercholesterolemia
AstraZeneca
2001-04 PHASE3
NCT00441844 COMPLETED
Type 1 Diabetes
University of California, Davis
2002-10 PHASE2
NCT00471549 COMPLETED
Type 2 Diabetes
University of Aarhus
1991-06 PHASE4
NCT00079638 COMPLETED
Dyslipidemia; Coronary Heart Disease; Atherosclerosis; Stroke; Diabetes
Kos Pharmaceuticals
2004-04 PHASE4
NCT00522158 COMPLETED
Type 2 Diabetes Mellitus; Cardiovascular Disease; LDL Cholesterol; Cognition
Baskent University
PHASE4
NCT00306826 WITHDRAWN
Glucose Metabolism Disorders
University of Leipzig
PHASE4
NCT00259441 COMPLETED
Kidney Failure
Seoul National University Hospital
2005-02 PHASE4
NCT00267267 TERMINATED
Hyperlipidemia; Dyslipidemia
Pfizer
2006-01 PHASE3
NCT00080275 COMPLETED
Hypercholesterolemia
Kos Pharmaceuticals
2004-03 PHASE3
NCT00365638 COMPLETED
Polycystic Ovary Syndrome
Poznan University of Medical Sciences
2004-04
NCT00399867 COMPLETED
Multiple Myeloma
Ludwig-Maximilians - University of Munich
2005-04 PHASE2
NCT00396513 UNKNOWN
Polycystic Ovary Syndrome
Poznan University of Medical Sciences
2005-09
NCT00125060 COMPLETED
Heart Diseases
Johns Hopkins University
2000-08
NCT00291863 UNKNOWN
Renal Failure, End Stage; Peritoneal Dialysis
Federal University of São Paulo
2006-02 PHASE4
NCT00365001 COMPLETED
Rheumatoid Arthritis
Hoffmann-La Roche
PHASE1
NCT00654173 COMPLETED
Hypercholesterolemia
AstraZeneca
2002-06 PHASE3
NCT00267254 COMPLETED
Hyperlipidemia; Dyslipidemia; Hypercholesterolemia
Pfizer
2006-01 PHASE3
NCT00712049 UNKNOWN
Dyslipidemia; Atherosclerosis
Medical University of Vienna
2008-06 PHASE4
NCT00189085 COMPLETED
Metabolic Syndrome
UMC Utrecht
2004-12 PHASE4
NCT00000941 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
PHASE1
NCT00185107 COMPLETED
Hypercholesterolemia
Daiichi Sankyo
2005-03 PHASE4
NCT00017758 COMPLETED
HIV Infections; HIV Seronegativity; Lipodystrophy
National Institute of Allergy and Infectious Diseases (NIAID)
PHASE1
NCT00281476 COMPLETED
Multiple Myeloma
Vejle Hospital
2006-02 PHASE1; PHASE2
NCT00313859 COMPLETED
Colorectal Cancer; Metastasis
Samsung Medical Center
2005-09 PHASE2
NCT00141141 COMPLETED
Hypercholesterolemia
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
2004-01 PHASE4
NCT00109382 COMPLETED
Transient Ischemic Attack; Stroke
University of Calgary
2003-05 PHASE2; PHASE3
NCT00466401 COMPLETED
Hypercholesterolemia
Ziv Hospital
2005-02 PHASE4
NCT00285181 COMPLETED
Healthy
University Hospital, Montpellier
2005-11
NCT00351286 UNKNOWN
Peripheral Arterial Disease; Intermittent Claudication
Angiogenix
2006-03 PHASE2
NCT00309374 COMPLETED
Endotoxemia
Medical University of Vienna
2006-03 PHASE1
NCT00000553 COMPLETED
Cardiovascular Diseases; Coronary Disease; Heart Diseases; Myocardial Ischemia
University of Washington
1994-09 PHASE3
NCT00566267 COMPLETED
Hyperlipidemia
Merck Sharp & Dohme LLC
2006-04 PHASE2; PHASE3
NCT00429442 WITHDRAWN
Relapsing Remitting Multiple Sclerosis
Anna Tsakiri
2008-03 PHASE3
NCT00365742 COMPLETED
Hyperlipidemia
Chestnut Hill Health System
2006-04
NCT00466869 TERMINATED
Hypercholesterolemia
OBEcure Ltd.
2007-05 PHASE2
NCT00159835 COMPLETED
Cardiovascular Diseases
Pfizer
1999-02 PHASE4
NCT00654407 COMPLETED
Hypercholesterolemia
AstraZeneca
2001-11 PHASE3
NCT00575601 COMPLETED
Polycystic Ovary Syndrome
Tehran University of Medical Sciences
2007-08 PHASE3
NCT00450840 UNKNOWN
Septic Shock
Medical University of Vienna
PHASE4

(data from https://clinicaltrials.gov, updated on 2026-08-31)

Check the Simvastatin (MK-733) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Simvastatin competitively binds to HMG-CoA reductase, inhibiting the conversion of HMG-CoA to mevalonate and subsequently suppressing intracellular cholesterol biosynthesis while inducing cellular autophagy and apoptosis. This suppression of endogenous cholesterol production promotes low-density lipoprotein clearance, establishing its therapeutic relevance in clinical trials evaluating cardiovascular diseases, atherosclerosis, and dyslipidemias.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

Note: Technical data last updated: Sep 1, 2026.