CAS No. 54952-43-1
| IUPAC Name | 5,8-dihydroxy-2-(1-hydroxy-4-methylpent-3-enyl)naphthalene-1,4-dione | |
|---|---|---|
| CAS Number | 54952-43-1 | |
| Molecular Formula |
C16H16O5 |
|
| Molecular Weight (MW) | 288.30 | |
| InChIKey | NEZONWMXZKDMKF-UHFFFAOYSA-N |
(Rac)-Shikonin is a potent and specific inhibitor of pyruvate kinase M2 (PKM2) that also inhibits TMEM16A chloride channel activity. By targeting PKM2, it disrupts aerobic glycolysis in tumor cells. Furthermore, (Rac)-Shikonin exerts significant anti-inflammatory effects by suppressing tumor necrosis factor-α (TNF-α) production and inhibiting the NF-κB signaling pathway through targeted proteasome inhibition, ultimately suppressing cellular proliferation and inflammatory responses.
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
57 mg/mL
(197.71 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 21 mg/mL |
| Water | Insoluble |
| DMSO |
57 mg/mL
(197.71 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 15 mg/mL |
| Water | Insoluble |
| DMSO |
57 mg/mL
(197.71 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 20 mg/mL |
| Water | Insoluble |
| DMSO |
57 mg/mL
(197.71 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 23 mg/mL |
| Water | Insoluble |
| DMSO |
57 mg/mL
(197.71 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 15 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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