CAS No. 1456632-40-8

Batch: Purity:99.96
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SH-4-54 Chemical Structure
Chemical Structure
Check the SH-4-54 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[(4-cyclohexylphenyl)methyl-[2-[methyl-(2,3,4,5,6-pentafluorophenyl)sulfonylamino]acetyl]amino]benzoic acid
CAS Number 1456632-40-8
Molecular Formula

C29H27F5N2O5S 
Molecular Weight (MW) 610.59
SMILES CN(CC(=O)N(CC1=CC=C(C=C1)C2CCCCC2)C3=CC=C(C=C3)C(=O)O)S(=O)(=O)C4=C(C(=C(C(=C4F)F)F)F)F
InChIKey VFPYGNNOSJWBHF-UHFFFAOYSA-N

Biological Activity

SH-4-54 is a potent STAT inhibitor that targets STAT3 (Kd of 300 nM) and STAT5 (Kd of. By blocking STAT3 and STAT5 phosphorylation and transcriptional activity, SH-4-54 suppresses downstream signal transduction through STAT pathways. This inhibition reduces expression of key downstream targets, leading to impaired cell proliferation, suppression of stemness markers, and induction of apoptosis in brain tumor stem cells and glioblastoma models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (163.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Haftchenary S, et al. ACS Med Chem Lett. 2013;4(11):1102-7.

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Note: Technical data last updated: Sep 1, 2026.