CAS No. 79559-97-0

Batch: Purity:99.97
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Sertraline HCl Chemical Structure
Chemical Structure
Check the Sertraline HCl product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 79559-97-0
Molecular Formula

C17H17Cl2N.HCl
Molecular Weight (MW) 342.69
SMILES CNC1CCC(C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl.Cl

Ordering Information

Biological Activity

Sertraline HCl is a selective serotonin reuptake inhibitor that targets the serotonin transporter (SERT). By inhibiting SERT-mediated reuptake of serotonin into presynaptic terminals, it increases extracellular serotonin concentrations and enhances central serotonergic neurotransmission. Sertraline HCl modulates downstream serotonergic signaling pathways to influence neuronal excitability, synaptic plasticity, and behavioral responses in cellular and animal models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 69 mg/mL (201.34 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 15 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.