CAS No. 99592-39-9
Batch:
Purity:99.75
Chemical Structure
Check the
Sertaconazole nitrate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 1-[2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole;nitric acid | |
|---|---|---|
| CAS Number | 99592-39-9 | |
| Molecular Formula |
C20H15Cl3N2OS.HNO3 |
|
| Molecular Weight (MW) | 500.78 | |
| SMILES | C1=CC2=C(C(=C1)Cl)SC=C2COC(CN3C=CN=C3)C4=C(C=C(C=C4)Cl)Cl.[N+](=O)(O)[O-] | |
| InChIKey | HAAITRDZHUANGT-UHFFFAOYSA-N |
Biological Activity
Sertaconazole nitrate is a broad-spectrum imidazole antifungal agent that targets fungal cytochrome P450 14α-demethylase. By inhibiting this enzyme, it disrupts ergosterol biosynthesis, compromising fungal cell membrane integrity and impairing cell viability. Additionally, sertaconazole nitrate exhibits anti-inflammatory activity by suppressing the production of pro-inflammatory cytokines, including TNF-α, IL-2, and IL-4, as well as prostaglandin E2 release, mitigating inflammatory responses. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(199.68 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
Jump to
- Sertaconazole nitrate Clinical Trials
- Sertaconazole nitrate Solubility in DMSO
- Sertaconazole nitrate Stock Solution
- Sertaconazole nitrate Storage
- Sertaconazole nitrate Stability
- Sertaconazole nitrate Molecular Weight
- Sertaconazole nitrate SMILES
- Sertaconazole nitrate Chemical Structure (2D and 3D)
- Sertaconazole nitrate SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.