CAS No. 910463-68-2(free base)
Batch:
Purity:99.74
Chemical Structure
Check the
Semaglutide Sodium
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 910463-68-2(free base) | |
|---|---|---|
| Molecular Formula |
C187H291N45O59 |
|
| Molecular Weight (MW) | 4113.58(free base) |
Semaglutide Sodium is a long-acting glucagon-like peptide-1 (GLP-1) analogue that functions as a potent GLP-1 receptor agonist. Selective binding to and activation of the GLP-1 receptor enhances intracellular cAMP signaling, which stimulates glucose-dependent insulin secretion from pancreatic beta cells while inhibiting glucagon release from alpha cells. Furthermore, GLP-1 receptor activation slows gastric emptying and promotes satiety, contributing to overall regulation of metabolic homeostasis. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 100 mg/mL |
| DMSO |
16 mg/mL
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.