CAS No. 27740-01-8

Batch: Purity:98.83
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Scutellarin Chemical Structure
Chemical Structure
Check the Scutellarin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 27740-01-8
Molecular Formula

C21H18O12
Molecular Weight (MW) 462.36
SMILES C1=CC(=CC=C1C2=CC(=O)C3=C(C(=C(C=C3O2)OC4C(C(C(C(O4)C(=O)O)O)O)O)O)O)O

Ordering Information

Biological Activity

Scutellarin is a natural flavonoid bioactive compound extracted from herbal plants such as Scutellaria baicalensis and Erigeron breviscapus. It suppresses STAT3/Girdin/Akt signaling in hepatocellular carcinoma cells and attenuates RANKL-mediated MAPK and NF-κB signaling pathways in osteoclasts. Downstream, these target modulations lead to inhibited cell proliferation and migration as well as reduced osteoclast formation and inflammatory responses.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 50 mg/mL (108.14 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 2 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.