CAS No. 14892-97-8
Batch:
Purity:99.61
Chemical Structure
Check the
SCR7
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 6,7-diphenyl-2-sulfanylidene-1H-pteridin-4-one | |
|---|---|---|
| CAS Number | 14892-97-8 | |
| Molecular Formula |
C18H12N4OS |
|
| Molecular Weight (MW) | 332.38 | |
| SMILES | C1=CC=C(C=C1)C2=NC3=C(NC(=S)NC3=O)N=C2C4=CC=CC=C4 | |
| InChIKey | GSRTWXVBHGOUBU-UHFFFAOYSA-N |
SCR7 is a selective DNA ligase IV inhibitor that blocks non-homologous end joining (NHEJ), a key pathway in DNA double-strand break repair. By suppressing NHEJ activity, SCR7 shunts repair pathways toward homology-directed repair (HDR), thereby enhancing HDR-mediated CRISPR/Cas9 genome editing efficiency in mammalian cells and mouse embryos. This selective inhibition promotes precise gene modifications while suppressing error-prone end joining. [1][2]
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
66 mg/mL
(198.56 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 23 mg/mL |
| Water | Insoluble |
| DMSO |
66 mg/mL
(198.56 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
| DMSO |
66 mg/mL
(198.56 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 22 mg/mL |
| Water | Insoluble |
| DMSO |
66 mg/mL
(198.56 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 4 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.