CAS No. 92-61-5

Batch: Purity:99.99
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Scopoletin Chemical Structure
Chemical Structure
Check the Scopoletin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 92-61-5
Molecular Formula

C10H8O4
Molecular Weight (MW) 192.17
SMILES COC1=C(C=C2C(=C1)C=CC(=O)O2)O

Ordering Information

Biological Activity

Scopoletin is a natural coumarin derivative and bioactive constituent that exhibits anti-inflammatory, hypouricemic, and antioxidant activities. It modulates inflammatory responses by inhibiting the NF-kB pathway and suppressing the production of proinflammatory mediators, including TNF-α, IL-6, and nitric oxide. Additionally, scopoletin reduces oxidative stress and xanthine oxidase activity, leading to attenuated hyperuricemic phenotypes and suppressed tissue inflammation in pre-clinical models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 38 mg/mL (197.74 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 10 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.