CAS No. 61281-37-6

Batch: Purity:99.98
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Schisandrin B Chemical Structure
Chemical Structure
Check the Schisandrin B product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 3,4,5,19-tetramethoxy-9,10-dimethyl-15,17-dioxatetracyclo[10.7.0.02,7.014,18]nonadeca-1(19),2,4,6,12,14(18)-hexaene
CAS Number 61281-37-6
Molecular Formula

C23H28O6
Molecular Weight (MW) 400.46
InChIKey RTZKSTLPRTWFEV-UHFFFAOYSA-N

Biological Activity

Schisandrin B is a dibenzocyclooctadiene lignan that acts as an inhibitor of ataxia telangiectasia and Rad3-related (ATR) kinase and P-glycoprotein (P-gp). By inhibiting ATR-mediated DNA damage signaling and suppressing P-gp-mediated drug efflux, Schisandrin B attenuates DNA damage checkpoint responses and enhances intracellular drug accumulation. These combined actions sensitize cancer cells to DNA-damaging therapeutics and overcome multidrug resistance in various preclinical tumor models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 80 mg/mL (199.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 10 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Cancer Letters. 2011;310(1):ii.

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Note: Technical data last updated: Sep 1, 2026.