CAS No. 316173-57-6

Batch: Purity:99.43
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SCH-442416 Chemical Structure
Chemical Structure
Check the SCH-442416 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-(furan-2-yl)-10-[3-(4-methoxyphenyl)propyl]-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7,11-pentaen-7-amine
CAS Number 316173-57-6
Molecular Formula

C20H19N7O2
Molecular Weight (MW) 389.41
SMILES COC1=CC=C(CCC[N]2N=CC3=C2N=C(N)[N]4N=C(N=C34)C5=CC=CO5)C=C1
InChIKey AEULVFLPCJOBCE-UHFFFAOYSA-N

Ordering Information

Biological Activity

SCH-442416 is a potent and selective antagonist targeting the adenosine A2A receptor. By selectively binding to the adenosine A2A receptor, SCH-442416 prevents endogenous ligand activation, thereby blocking Gs protein coupling and inhibiting adenylate cyclase activity. This downregulates intracellular cAMP levels, which modulates downstream dopaminergic signaling, regulates neurotransmitter release, and dampens neuroinflammatory responses within the central nervous system. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 78 mg/mL (200.3 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.