CAS No. 501951-42-4
| CAS Number | 501951-42-4 | |
|---|---|---|
| Molecular Formula |
C17H16BrF3N4O |
|
| Molecular Weight (MW) | 429.23 | |
| SMILES | C1CN(CC1NC(=O)NC2=CC=CC=C2Br)C3=NC=C(C=C3)C(F)(F)F |
SB705498 is a potent, selective transient receptor potential vanilloid 1 (TRPV1) antagonist that inhibits human TRPV1 activation induced by capsaicin, acid, and heat. By blocking TRPV1-mediated intracellular calcium influx and sensory neuron activation, it modulates nociceptive signaling pathways. SB705498 exhibits high selectivity for TRPV1 over other ion channels and shows robust antihyperalgesic activity in animal models of inflammatory and neuropathic pain. [1][2]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
86 mg/mL
(200.35 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 20 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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