CAS No. 618430-39-0
Chemical Structure
Check the
SB-743921
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | N-(3-aminopropyl)-N-[(1R)-1-(3-benzyl-7-chloro-4-oxochromen-2-yl)-2-methylpropyl]-4-methylbenzamide | |
|---|---|---|
| CAS Number | 618430-39-0 | |
| Molecular Formula |
C31H33ClN2O3.ClH |
|
| Molecular Weight (MW) | 553.52 | |
| InChIKey | PGXYIBJJCLWJST-MUUNZHRXSA-N |
Biological Activity
SB-743921 is a small-molecule inhibitor of kinesin spindle protein (KSP), a key motor protein required for mitotic spindle assembly and cell division. By inhibiting KSP function in rapidly dividing cells, it disrupts monopolar spindle bipolarization, resulting in cell cycle arrest at the G2/M phase and subsequent induction of apoptosis. In tumor models, targeting KSP impairs cellular motility, prevents successful mitosis, and suppresses cell proliferation. [1]
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Note: Technical data last updated: Sep 1, 2026.