CAS No. 84687-43-4

Batch: Purity:100.00
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Astragaloside IV Chemical Structure
Chemical Structure
Check the Astragaloside IV product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 84687-43-4
Molecular Formula

C41H68O14
Molecular Weight (MW) 784.97
SMILES CC1(C(CCC23C1C(CC4C2(C3)CCC5(C4(CC(C5C6(CCC(O6)C(C)(C)O)C)O)C)C)OC7C(C(C(C(O7)CO)O)O)O)OC8C(C(C(CO8)O)O)O)C

Ordering Information

Biological Activity

Astragaloside IV is a bioactive triterpene saponin that modulates key cellular pathways, including NF-kB, AKT/mTOR, and ERK1/2 signaling. By inhibiting the phosphorylation of p-Akt, p-mTOR, p-NF-kB, and p-Erk1/2, Astragaloside IV suppresses inflammatory responses, reduces cellular apoptosis, and protects against oxidative stress across diverse biological models. These signaling pathway modulations downregulate pro-inflammatory cytokines and promote cellular survival. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (127.39 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.