CAS No. 135159-51-2

Batch: Purity:99.77
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Sarpogrelate hydrochloride Chemical Structure
Chemical Structure
Check the Sarpogrelate hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 135159-51-2
Molecular Formula

C24H31NO6.HCl
Molecular Weight (MW) 465.97
SMILES CN(C)CC(COC1=CC=CC=C1CCC2=CC(=CC=C2)OC)OC(=O)CCC(=O)O.Cl

Biological Activity

Sarpogrelate hydrochloride is a selective antagonist of the serotonin 5-HT2A receptor, demonstrating higher binding affinity for 5-HT2A over 5-HT2C and 5-HT2B receptors. By selectively blocking 5-HT2A receptor signaling, it inhibits serotonin-induced platelet aggregation and vascular smooth muscle contraction. Downstream, these targeted interactions prevent thrombosis and attenuate vasoconstriction mediated by serotonergic pathways in cardiovascular tissue.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 93 mg/mL (199.58 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 93 mg/mL
Ethanol 31 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.