CAS No. 2114339-57-8

Batch: Purity:99.92
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Amcenestrant (SAR439859) Chemical Structure
Chemical Structure
Check the Amcenestrant (SAR439859) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 6-(2,4-dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid
CAS Number 2114339-57-8
Molecular Formula

C31H30Cl2FNO3
Molecular Weight (MW) 554.48
SMILES C1CC2=C(C=CC(=C2)C(=O)O)C(=C(C1)C3=C(C=C(C=C3)Cl)Cl)C4=CC=C(C=C4)OC5CCN(C5)CCCF
InChIKey KISZAGQTIXIVAR-VWLOTQADSA-N

Ordering Information

Biological Activity

Amcenestrant (SAR439859) is an orally bioavailable, nonsteroidal selective estrogen receptor degrader (SERD) that antagonizes estrogen receptor activity and induces ERα degradation with an EC50 of. By promoting proteasomal degradation of the estrogen receptor, Amcenestrant inhibits downstream ER signaling pathways, downregulates estrogen-dependent gene transcription, and potently suppresses cell proliferation and tumor growth in estrogen receptor-positive breast cancer models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (180.34 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.