CAS No. 1116743-46-4
Batch:
Purity:99.02
Chemical Structure
Check the
SAR125844
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-[6-[[6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl]-1,3-benzothiazol-2-yl]-3-(2-morpholin-4-ylethyl)urea | |
|---|---|---|
| CAS Number | 1116743-46-4 | |
| Molecular Formula |
C25H23FN8O2S2 |
|
| Molecular Weight (MW) | 550.63 | |
| SMILES | C1COCCN1CCNC(=O)NC2=NC3=C(S2)C=C(C=C3)SC4=NN=C5N4N=C(C=C5)C6=CC=C(C=C6)F | |
| InChIKey | ODIUNTQOXRXOIV-UHFFFAOYSA-N |
SAR125844 is a potent, intravenously active, and highly selective c-Met (Met) kinase inhibitor that targets both wild-type and mutant c-Met enzymes. By inhibiting c-Met receptor tyrosine kinase activity, SAR125844 blocks downstream HGF/c-Met signaling cascades, suppressing oncogenic signaling pathways such as PI3K/AKT and MAPK/ERK. This targeted inhibition results in reduced tumor cell proliferation, impaired cell survival, and regression of c-Met-amplified tumors in preclinical models. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
11 mg/mL
(19.97 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | ˂1 mg/mL |
| Ethanol | ˂1 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.