CAS No. 69056-38-8

Batch: Purity:99.82
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Sapropterin (Tetrahydrobiopterin) Dihydrochloride Chemical Structure
Chemical Structure
Check the Sapropterin (Tetrahydrobiopterin) Dihydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (6R)-2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-3H-pteridin-4-one;dihydrochloride
CAS Number 69056-38-8
Molecular Formula

C9H17Cl2N5O3
Molecular Weight (MW) 314.17
SMILES CC(C(C1CNC2=C(N1)C(=O)NC(=N2)N)O)O.Cl.Cl
InChIKey RKSUYBCOVNCALL-NTVURLEBSA-N

Biological Activity

Sapropterin (Tetrahydrobiopterin) Dihydrochloride is an activator of phenylalanine hydroxylase (PAH) and serves as a synthetic form of the essential enzyme cofactor tetrahydrobiopterin. By promoting the enzymatic activity of PAH, it facilitates the conversion of L-phenylalanine to L-tyrosine, a key step in phenylalanine catabolism. This activation restores metabolic flux through the aromatic amino acid hydroxylase pathway and reduces cellular toxicity associated with excess phenylalanine.

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (318.29 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 100 mg/mL
Ethanol ˂1 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.