CAS No. 20874-52-6

Batch: Purity:99.90
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Saikosaponin D Chemical Structure
Chemical Structure
Check the Saikosaponin D product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 20874-52-6
Molecular Formula

C42H68O13
Molecular Weight (MW) 780.98
SMILES CC1OC(OC2CCC3(C)C(CCC4(C)C3C=CC56OCC7(CCC(C)(C)CC57)C(O)CC46C)C2(C)CO)C(O)C(OC8OC(CO)C(O)C(O)C8O)C1O

Ordering Information

Biological Activity

Saikosaponin D is a natural triterpenoid saponin derived from Bupleurum falcatum that acts as a calcium-mobilizing agent and sarco/endoplasmic reticulum Ca²⁺-ATPase (SERCA) inhibitor. By targeting SERCA, it disrupts intracellular calcium homeostasis and activates CaMKKβ-AMPK signaling while suppressing mTOR pathway signaling. These targeted alterations subsequently trigger autophagy and induce apoptotic cell death in cancer cells.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (128.04 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.