CAS No. 1228108-65-3
Batch:
Purity:99.51
Chemical Structure
Check the
Sabutoclax
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 2,3,5-trihydroxy-7-methyl-N-[(2R)-2-phenylpropyl]-6-[1,6,7-trihydroxy-3-methyl-5-[[(2R)-2-phenylpropyl]carbamoyl]naphthalen-2-yl]naphthalene-1-carboxamide | |
|---|---|---|
| CAS Number | 1228108-65-3 | |
| Molecular Formula |
C42H40N2O8 |
|
| Molecular Weight (MW) | 700.78 | |
| SMILES | CC1=CC2=C(C(=C(C=C2C(=C1C3=C(C4=CC(=C(C(=C4C=C3C)C(=O)NCC(C)C5=CC=CC=C5)O)O)O)O)O)O)C(=O)NCC(C)C6=CC=CC=C6 | |
| InChIKey | RAYNZUHYMMLQQA-ZEQRLZLVSA-N |
Biological Activity
Sabutoclax (BI-97C1) is a pan-Bcl-2 inhibitor targeting Mcl-1 (IC50 0.20 μM), Bcl-xL (IC50 0.31 μM), Bcl-2 (IC50 0.32 μM), and Bfl-1 (IC50 0.62 μM). By inhibiting these anti-apoptotic Bcl-2 family proteins, it disrupts mitochondrial outer membrane integrity, activates caspases, and triggers intrinsic apoptosis. Consequently, Sabutoclax suppresses cancer cell growth and overcomes therapy resistance across various preclinical malignancy models. [1]
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(142.69 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 26 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(142.69 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 25 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(142.69 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 25 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
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Note: Technical data last updated: Sep 1, 2026.