S63845 is a potent, selective MCL-1 inhibitor. It affects BAX/BAK-dependent apoptosis and interferon signaling pathways by binding to the MCL-1 BH3 groove and displacing pro-apoptotic proteins, effectively promoting caspase-dependent apoptosis in cancer cells.
S63845 IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for S63845 Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.