CAS No. 867-44-7

Batch: Purity:99.66
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(S)-Methylisothiourea sulfate Chemical Structure
Chemical Structure
Check the (S)-Methylisothiourea sulfate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name methyl carbamimidothioate;sulfuric acid
CAS Number 867-44-7
Molecular Formula

C2H6N2S.1/2 H2SO4
Molecular Weight (MW) 139.19
SMILES CSC(=N)N.CSC(=N)N.OS(=O)(=O)O
InChIKey BZZXQZOBAUXLHZ-UHFFFAOYSA-N

Biological Activity

(S)-Methylisothiourea sulfate is a potent inhibitor of inducible nitric oxide synthase (iNOS). By suppressing iNOS enzyme activity, it blocks the overproduction of intracellular nitric oxide and attenuates downstream NO-mediated inflammatory signaling pathways. This inhibition effectively reduces vascular hyporeactivity, decreases oxidative stress, and protects against cytokine-induced tissue damage and vascular dysfunction in various inflammatory and endotoxemic disease models.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 27 mg/mL
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.