CAS No. 486-56-6
Batch:
Purity:
Chemical Structure
Check the
S-(-)-Cotinine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 486-56-6 | |
|---|---|---|
| Molecular Formula |
C10H12N2O |
|
| Molecular Weight (MW) | 176.22 |
S-(-)-Cotinine is a major tobacco constituent and nicotine metabolite that acts as an agonist of neuronal nicotinic acetylcholine receptors. By stimulating these nicotinic receptors, it evokes dopamine release in a calcium-dependent manner within striatal tissues. This activity modulates central dopaminergic neurotransmission, downstream neural signaling pathways, and neurochemical responses associated with nicotine exposure and reward mechanisms. [1]
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.