CAS No. 2757470-18-9
Batch:
Purity:99.7
Chemical Structure
Check the
Ensitrelvir fumarate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | (E)-but-2-enedioic acid;6-[(6-chloro-2-methylindazol-5-yl)amino]-3-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-[(2,4,5-trifluorophenyl)methyl]-1,3,5-triazine-2,4-dione | |
|---|---|---|
| CAS Number | 2757470-18-9 | |
| Molecular Formula |
C22H17ClF3N9O2.C4H4O4 |
|
| Molecular Weight (MW) | 647.95 | |
| SMILES | C[N]1C=NC(=N1)CN2C(=O)NC(=NC3=CC4=C[N](C)N=C4C=C3Cl)N(CC5=C(F)C=C(F)C(=C5)F)C2=O.OC(=O)\C=C\C(O)=O | |
| InChIKey | FBOCUALVLIWPNQ-WLHGVMLRSA-N |
Biological Activity
Ensitrelvir fumarate (S-217622) is an orally active, non-covalent, and non-peptidic SARS-CoV-2 3C-like (3CL) protease inhibitor with an IC of. By selectively targeting the catalytic active site of 3CL protease, it blocks the cleavage of viral polyproteins required for viral assembly. This selective inhibition disrupts SARS-CoV-2 replication and suppresses downstream viral proliferation across multiple viral variants. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
50 mg/mL
(77.16 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
Jump to
- Ensitrelvir fumarate Clinical Trials
- Ensitrelvir fumarate Solubility in DMSO
- Ensitrelvir fumarate Stock Solution
- Ensitrelvir fumarate Storage
- Ensitrelvir fumarate Stability
- Ensitrelvir fumarate Molecular Weight
- Ensitrelvir fumarate SMILES
- Ensitrelvir fumarate Chemical Structure (2D and 3D)
- Ensitrelvir fumarate SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.