CAS No. 182349-12-8
Batch:
Purity:99.69
Chemical Structure
Check the
Rupatadine Fumarate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (E)-but-2-enedioic acid;13-chloro-2-[1-[(5-methyl-3-pyridinyl)methyl]piperidin-4-ylidene]-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaene | |
|---|---|---|
| CAS Number | 182349-12-8 | |
| Molecular Formula |
C26H26ClN3.C4H4O4 |
|
| Molecular Weight (MW) | 532.03 | |
| SMILES | CC1=CC(=CN=C1)CN2CCC(=C3C4=C(CCC5=C3N=CC=C5)C=C(C=C4)Cl)CC2.C(=CC(=O)O)C(=O)O | |
| InChIKey | JYBLCDXVHQWMSU-WLHGVMLRSA-N |
Rupatadine Fumarate is a dual antagonist of the histamine H1 receptor and PAFR. By blocking both histamine- and platelet-activating factor (PAF)-mediated signaling pathways, it suppresses vascular permeability, inflammatory cell recruitment, and airway hyperresponsiveness. Consequently, Rupatadine inhibits downstream allergic inflammatory cascades and attenuates mediator-induced cutaneous and respiratory responses in preclinical models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Ethanol | 13 mg/mL |
| DMSO |
9 mg/mL
(16.91 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Rupatadine Fumarate Clinical Trials
- Rupatadine Fumarate Solubility in DMSO
- Rupatadine Fumarate Stock Solution
- Rupatadine Fumarate Storage
- Rupatadine Fumarate Stability
- Rupatadine Fumarate Molecular Weight
- Rupatadine Fumarate SMILES
- Rupatadine Fumarate Chemical Structure (2D and 3D)
- Rupatadine Fumarate SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.