CAS No. 1859053-21-6

Batch: Purity:99.96
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Rucaparib Camsylate Chemical Structure
Chemical Structure
Check the Rucaparib Camsylate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name [(1S,4R)-7,7-dimethyl-2-oxo-1-bicyclo[2.2.1]heptanyl]methanesulfonic acid;6-fluoro-2-[4-(methylaminomethyl)phenyl]-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4,6,8(13)-tetraen-9-one
CAS Number 1859053-21-6
Molecular Formula

C29H34FN3O5S
Molecular Weight (MW) 555.66
SMILES CNCC1=CC=C(C=C1)C2=C3CCNC(=O)C4=C3C(=CC(=C4)F)[NH]2.CC5(C)C6CCC5(C[S](O)(=O)=O)C(=O)C6
InChIKey INBJJAFXHQQSRW-STOWLHSFSA-N

Ordering Information

Biological Activity

Rucaparib Camsylate is a potent inhibitor of PARP1 (Ki 1.4 nM) that also displays binding affinity across multiple PARP catalytic domains. By inhibiting poly(ADP-ribosyl)ation and blocking base excision repair, it prevents efficient DNA single-strand break repair. This leads to persistent DNA damage, accumulation of cytotoxic double-strand DNA breaks, and synthetic lethality in homologous recombination-deficient cancer cells. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (179.96 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.