CAS No. 99755-59-6
| IUPAC Name | (6S)-6-[propyl(2-thiophen-2-ylethyl)amino]-5,6,7,8-tetrahydronaphthalen-1-ol | |
|---|---|---|
| CAS Number | 99755-59-6 | |
| Molecular Formula |
C19H25NOS |
|
| Molecular Weight (MW) | 315.47 | |
| SMILES | CCCN(CCC1=CC=CS1)C2CCC3=C(C2)C=CC=C3O | |
| InChIKey | KFQYTPMOWPVWEJ-INIZCTEOSA-N |
Rotigotine is a non-ergoline dopamine receptor agonist that acts as a potent activator of dopamine D1, D2, and D3 receptors. By activating D2-like and D1-like dopamine receptors, rotigotine stimulates downstream dopaminergic signaling pathways to regulate intracellular cAMP levels and neural transmission. These receptor-mediated actions enhance central dopaminergic tone, improving motor coordination and functional signaling in dopaminergic depletion models. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
63 mg/mL
(199.7 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 63 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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