CAS No. 84057-95-4
Batch:
Purity:99.99
Chemical Structure
Check the
Ropivacaine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 84057-95-4 | |
|---|---|---|
| Molecular Formula |
C17H26N2O |
|
| Molecular Weight (MW) | 274.40 | |
| SMILES | CCCN1CCCCC1C(=O)NC2=C(C=CC=C2C)C |
Biological Activity
Ropivacaine is an amino amide local anesthetic that functions as a potent voltage-gated sodium channel inhibitor. By reversibly binding to sodium channels, it blocks sodium ion influx across the neuronal membrane, preventing depolarization and action potential propagation. This blockade attenuates sensory signal transmission along peripheral nerve fibers, effectively suppressing downstream nociceptive pathways. [1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
23 mg/mL
(83.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.