CAS No. 213261-59-7
Batch:
Purity:99.93
Chemical Structure
Check the
RITA
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | [5-[5-[5-(hydroxymethyl)thiophen-2-yl]furan-2-yl]thiophen-2-yl]methanol | |
|---|---|---|
| CAS Number | 213261-59-7 | |
| Molecular Formula |
C14H12O3S2 |
|
| Molecular Weight (MW) | 292.37 | |
| SMILES | C1=C(SC(=C1)C2=CC=C(O2)C3=CC=C(S3)CO)CO | |
| InChIKey | KZENBFUSKMWCJF-UHFFFAOYSA-N |
RITA (NSC 652287) is a small-molecule p53 activator that directly binds to p53 and inhibits the p53-MDM2 interaction. By blocking p53 ubiquitination and degradation, RITA induces cellular p53 accumulation and activates p53-mediated transcriptional pathways. These biochemical effects lead to robust cell cycle arrest and p53-dependent apoptosis in tumor cell lines, suppressing tumor growth both in vitro and in vivo. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
58 mg/mL
(198.37 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 8 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.