CAS No. 887375-67-9
Batch:
Purity:99.22
Chemical Structure
Check the
Ripasudil hydrochloride dihydrate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 4-fluoro-5-[[(2S)-2-methyl-1,4-diazepan-1-yl]sulfonyl]isoquinoline;dihydrate;hydrochloride | |
|---|---|---|
| CAS Number | 887375-67-9 | |
| Molecular Formula |
C15H18FN3O2S.Cl H.2 H2 O |
|
| Molecular Weight (MW) | 395.88 | |
| SMILES | CC1CNCCCN1S(=O)(=O)C2=CC=CC3=CN=CC(=C32)F.O.O.Cl | |
| InChIKey | CMDJNMACGABCKQ-XVSRHIFFSA-N |
Biological Activity
Ripasudil hydrochloride dihydrate is a potent ROCK inhibitor that targets ROCK1 (IC50 51 nM) and ROCK2 (IC50 19 nM). By inhibiting Rho-kinase activity, it modulates cytoskeletal re-organization, reduces actomyosin contractility, and promotes trabecular meshwork cell relaxation. This cellular action enhances aqueous humor outflow facility, leading to reduced intraocular pressure and suppressed retinal ganglion cell death in preclinical models. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 79 mg/mL |
| DMSO |
26 mg/mL
(65.67 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
Jump to
- Ripasudil hydrochloride dihydrate Clinical Trials
- Ripasudil hydrochloride dihydrate Solubility in DMSO
- Ripasudil hydrochloride dihydrate Stock Solution
- Ripasudil hydrochloride dihydrate Storage
- Ripasudil hydrochloride dihydrate Stability
- Ripasudil hydrochloride dihydrate Molecular Weight
- Ripasudil hydrochloride dihydrate SMILES
- Ripasudil hydrochloride dihydrate Chemical Structure (2D and 3D)
- Ripasudil hydrochloride dihydrate SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.