CAS No. 887375-67-9

Batch: Purity:99.22
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Ripasudil hydrochloride dihydrate Chemical Structure
Chemical Structure
Check the Ripasudil hydrochloride dihydrate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-fluoro-5-[[(2S)-2-methyl-1,4-diazepan-1-yl]sulfonyl]isoquinoline;dihydrate;hydrochloride
CAS Number 887375-67-9
Molecular Formula

C15H18FN3O2S.Cl H.2 H2 O
Molecular Weight (MW) 395.88
SMILES CC1CNCCCN1S(=O)(=O)C2=CC=CC3=CN=CC(=C32)F.O.O.Cl
InChIKey CMDJNMACGABCKQ-XVSRHIFFSA-N

Ordering Information

Biological Activity

Ripasudil hydrochloride dihydrate is a potent ROCK inhibitor that targets ROCK1 (IC50 51 nM) and ROCK2 (IC50 19 nM). By inhibiting Rho-kinase activity, it modulates cytoskeletal re-organization, reduces actomyosin contractility, and promotes trabecular meshwork cell relaxation. This cellular action enhances aqueous humor outflow facility, leading to reduced intraocular pressure and suppressed retinal ganglion cell death in preclinical models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 79 mg/mL
DMSO 26 mg/mL (65.67 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 5 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.