CAS No. 195514-63-7
| IUPAC Name | [(1R)-3-(3,4-dimethoxyphenyl)-1-[3-[2-[2-[[2-[3-[(1R)-3-(3,4-dimethoxyphenyl)-1-[(2S)-1-[(2S)-2-(3,4,5-trimethoxyphenyl)butanoyl]piperidine-2-carbonyl]oxypropyl]phenoxy]acetyl]amino]ethylamino]-2-oxoethoxy]phenyl]propyl] (2S)-1-[(2S)-2-(3,4,5-trimethoxyphenyl)butanoyl]piperidine-2-carboxylate | |
|---|---|---|
| CAS Number | 195514-63-7 | |
| Molecular Formula |
C78H98N4O20 |
|
| Molecular Weight (MW) | 1411.63 | |
| SMILES | CCC(C(=O)N1CCCCC1C(=O)OC(CCC2=CC(=C(OC)C=C2)OC)C3=CC(=CC=C3)OCC(=O)NCCNC(=O)COC4=CC=CC(=C4)C(CCC5=CC(=C(OC)C=C5)OC)OC(=O)C6CCCCN6C(=O)C(CC)C7=CC(=C(OC)C(=C7)OC)OC)C8=CC(=C(OC)C(=C8)OC)OC | |
| InChIKey | GQLCLPLEEOUJQC-ZTQDTCGGSA-N |
Rimiducid (AP1903) is a synthetic chemical dimerizer that selectively binds mutant FKBP12(F36V) fusion proteins with subnanomolar affinity while showing minimal binding to endogenous wild-type FKBP12. By inducing the homodimerization or oligomerization of FKBP-containing chimeric receptors or enzymes, such as Fas or caspase signaling constructs, rimiducid activates downstream pro-apoptotic pathways. This targeted dimerization triggers potent, dose-dependent apoptosis in cells expressing dimerizer-dependent constructs, serving as an inducible cell safety switch. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(70.84 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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- Rimiducid (AP1903) Clinical Trials
- Rimiducid (AP1903) Solubility in DMSO
- Rimiducid (AP1903) Stock Solution
- Rimiducid (AP1903) Storage
- Rimiducid (AP1903) Stability
- Rimiducid (AP1903) Molecular Weight
- Rimiducid (AP1903) SMILES
- Rimiducid (AP1903) Chemical Structure (2D and 3D)
- Rimiducid (AP1903) SDS｜MSDS