SMILES:
CN(C)C(=O)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=NC=C(C=C4)N5CCNCC5
Chemical Structure
Check the
LEE011 (Ribociclib)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 7-cyclopentyl-N,N-dimethyl-2-[(5-piperazin-1-yl-2-pyridinyl)amino]pyrrolo[2,3-d]pyrimidine-6-carboxamide | |
|---|---|---|
| CAS Number | 1211441-98-3 | |
| Molecular Formula |
C23H30N8O |
|
| Molecular Weight (MW) | 434.54 | |
| SMILES | CN(C)C(=O)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=NC=C(C=C4)N5CCNCC5 | |
| InChIKey | RHXHGRAEPCAFML-UHFFFAOYSA-N |
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
8 mg/mL
(18.41 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
8 mg/mL
(18.41 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
7 mg/mL
(16.1 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
22 mg/mL
(50.62 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
20 mg/mL
(46.02 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- LEE011 (Ribociclib) Mechanism of Action: CDK4/6 Inhibition in HR+/HER2- Breast Cancer Cell Research
- LEE011 (Ribociclib) Clinical Trials
- LEE011 (Ribociclib): Selectivity & Specificity
- LEE011 (Ribociclib) Working Concentration | Cell Culture | Treatment
- LEE011 (Ribociclib) Solubility in DMSO
- LEE011 (Ribociclib) Stock Solution
- LEE011 (Ribociclib) Storage
- LEE011 (Ribociclib) Stability
- LEE011 (Ribociclib) Combination Database
- LEE011 (Ribociclib) Molecular Weight
- LEE011 (Ribociclib) CAS Number
- LEE011 (Ribociclib) Chemical Structure (2D and 3D)
- LEE011 (Ribociclib) IC50 for Cell-based and Cell-free Assays
- LEE011 (Ribociclib) Sigma (AMBH2D6FB2BC)? Try a better option.
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- LEE011 (Ribociclib) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.