CAS No. 415713-60-9
Batch:
Purity:99.48
Chemical Structure
Check the
RI-1
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-chloro-1-(3,4-dichlorophenyl)-4-morpholin-4-ylpyrrole-2,5-dione | |
|---|---|---|
| CAS Number | 415713-60-9 | |
| Molecular Formula |
C14H11Cl3N2O3 |
|
| Molecular Weight (MW) | 361.61 | |
| SMILES | C1COCCN1C2=C(C(=O)N(C2=O)C3=CC(=C(C=C3)Cl)Cl)Cl | |
| InChIKey | MWSUIZKGNWELRF-UHFFFAOYSA-N |
RI-1 is a selective RAD51 inhibitor with IC50 values ranging from 5 to. It covalently modifies cysteine 319 of RAD51, thereby destabilizing nucleoprotein filament formation and disrupting homologous recombination repair in human cells. Consequently, RI-1 impairs DNA double-strand break repair, inhibits cancer cell proliferation, and sensitizes tumor cells to DNA-damaging therapy. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
50 mg/mL
(138.27 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.