CAS No. 2169919-21-3

Batch: Purity:99.93
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SNDX-5613 (Revumenib) Chemical Structure
Chemical Structure
Check the SNDX-5613 (Revumenib) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-ethyl-2-[4-[7-[[4-(ethylsulfonylamino)cyclohexyl]methyl]-2,7-diazaspiro[3.5]nonan-2-yl]pyrimidin-5-yl]oxy-5-fluoro-N-propan-2-ylbenzamide
CAS Number 2169919-21-3
Molecular Formula

C32H47FN6O4S
Molecular Weight (MW) 630.82
SMILES CCN(C(C)C)C(=O)C1=C(OC2=CN=CN=C2N3CC4(CCN(CC4)CC5CCC(CC5)N[S](=O)(=O)CC)C3)C=CC(=C1)F
InChIKey FRVSRBKUQZKTOW-UHFFFAOYSA-N

Ordering Information

Biological Activity

Revumenib (SNDX-5613) is a potent and selective inhibitor of the menin-MLL interaction. By disrupting menin binding to MLL fusion proteins, it downregulates critical downstream leukemogenic targets, including HOXA9 and MEIS1 expression. Consequently, revumenib inhibits cellular proliferation and induces differentiation and apoptosis across multiple MLL-rearranged leukemia cell lines, suppressing oncogenic signaling and leukemic cell survival.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 25 mg/mL (39.63 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 25 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.