Clinical Trials

Numerous clinical trials evaluate retinoic acid from early-phase through phase 4 investigations, encompassing recruiting, active, and completed recruitment statuses. Research heavily focuses on hematologic and oncological disorders—particularly acute promyelocytic leukemia, acute myelogenous leukemia, and breast cancer—alongside melasma and SARS-CoV-2 infection. Sponsored by academic institutions and research consortia such as Assiut University, Peking University People's Hospital, and the European Organisation for Research and Treatment of Cancer, these studies explore diverse therapeutic approaches, including oral induction and combination regimens.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03126916 RECRUITING
Ganglioneuroblastoma; Ganglioneuroblastoma, Nodular; Neuroblastoma
Children's Oncology Group
 2018-05-14 PHASE3
NCT06172296 RECRUITING
Ganglioneuroblastoma, Nodular; Neuroblastoma
National Cancer Institute (NCI)
 2024-04-19 PHASE3
NCT06703047 NOT_YET_RECRUITING
Esophageal Squamous Cell Carcinoma
Fudan University
 2024-11-20 PHASE2
NCT06636981 RECRUITING
Triple Negative Breast Cancer (TNBC)
Fudan University
 2024-11-04 PHASE2
NCT06536413 RECRUITING
Multiple Myeloma
The Methodist Hospital Research Institute
 2024-07-29 PHASE1; PHASE2
NCT07355855 NOT_YET_RECRUITING
Rhabdomyosarcoma
Fudan University
 2026-01 PHASE2
NCT06706401 RECRUITING
Oropharynx Cancer; Larynx Cancer; Hypopharynx Cancer; Primary Head and Neck Tumor
Centre Leon Berard
 2025-02-20 PHASE3
NCT06841952 NOT_YET_RECRUITING
AML, Adult
The First Affiliated Hospital of Soochow University
 2025-02-15
NCT07278908 NOT_YET_RECRUITING
ITP - Immune Thrombocytopenia
Institute of Hematology & Blood Diseases Hospital, China
 2025-12 PHASE2; PHASE3
NCT07626398 NOT_YET_RECRUITING
Hemophagocytic Lymphohistiocytosis (HLH)
Beijing Anzhen Hospital
 2026-06-01 PHASE2; PHASE3
NCT05384821 RECRUITING
Wilms Tumor
Centre Oscar Lambret
 2022-09-14 PHASE1; PHASE2
NCT06528769 RECRUITING
Leiomyosarcoma; Sarcoma
Gabriel Tinoco
 2025-09-10 PHASE2
NCT07597395 NOT_YET_RECRUITING
Immune Thrombocytopenia
Peking University People's Hospital
 2026-05-30 PHASE3
NCT01409161 RECRUITING
Acute Promyelocytic Leukemia With PML-RARA
M.D. Anderson Cancer Center
 2011-10-05 PHASE2
NCT06698263 NOT_YET_RECRUITING
Men with Infertility
University Hospital, Strasbourg, France
 2025-03-01 PHASE4
NCT06484920 RECRUITING
Relapsed Hodgkin Lymphoma; Refractory Hodgkin Lymphoma; Relapsed Non-Hodgkin Lymphoma; Refractory Non-Hodgkin Lymphoma; B-cell Lymphoma
Rita Assi
 2024-11-18 PHASE2
NCT07586813 RECRUITING
Persistent Isolated Chemotherapy-Induced Thrombocytopenia; Chemotherapy-Induced Thrombocytopenia; Gastrointestinal Neoplasms; Pancreatic Cancer; Colorectal Cancer
Peking University People's Hospital
 2025-12-22 PHASE2
NCT07586826 RECRUITING
Persistent Isolated Chemotherapy-Induced Thrombocytopenia; Chemotherapy-Induced Thrombocytopenia; Gynecologic Cancers; Ovarian Cancer; Breast Cancer; Lung Cancer; Non-Small Cell Lung Cancer; Cervical Cancer; Fallopian Tube Cancer; Primary Peritoneal Cancer
Peking University People's Hospital
 2025-12-22 PHASE2
NCT07187505 ACTIVE_NOT_RECRUITING
Acute Promyelocytic Leukemia (APL)
Anhui Medical University
 2025-07-01
NCT06358677 RECRUITING
Metastatic Solid Tumor; Locally Advanced Solid Tumor
University of Utah
 2025-02-19 PHASE2
NCT05345002 RECRUITING
Glioma; IDH Mutation; Astrocytoma; Oligodendroglioma
Stephen Bagley, MD, MSCE
 2022-11-16 PHASE2
NCT06646666 NOT_YET_RECRUITING
B-cell Non Hodgkin Lymphoma
Ruijin Hospital
 2024-12-01 PHASE2
NCT07296445 NOT_YET_RECRUITING
Acute Promyelocytic Leukemia (APL); Acute Promyelocytic Leukaemia; Acute Promyelocytic Leukemia With PML-RARA; Acute Promyelocytic Leukemia With t(15;17)(q24.1;q21.2); PML-RARA; APL; Acute Promyelocytic Leukemia; Leukaemia; Leukemia Acute Promyelocytic Leukemia (APL); Leukemia, Acute
SDK Therapeutics, Inc.
 2026-01 PHASE3
NCT07504458 RECRUITING
Acute Promyelocytic Leukemia (APL); Acute Promyelocytic Leukaemia; Acute Promyelocytic Leukemia With PML-RARA; Acute Promyelocytic Leukemia With t(15;17)(q24.1;q21.2); PML-RARA; Acute Promyelocytic Leukemia
Quetzal Therapeutics
 2026-06-08 PHASE3
NCT07732192 NOT_YET_RECRUITING
Melasma; Melasma (Facial Melasma)
Combined Military Hospital Abbottabad
 2026-07-15 PHASE4
NCT07079696 NOT_YET_RECRUITING
Dup15q Syndrome; Autism Spectrum Disorder; Therapy; All-trans Retinoic Acid
Second Affiliated Hospital, Zhejiang University, School of Medicine
 2025-09-01 PHASE2
NCT05999812 ACTIVE_NOT_RECRUITING
Colorectal Cancer
University of Texas Southwestern Medical Center
 2023-12-19 PHASE2
NCT06731140 RECRUITING
HER2 Negative Breast Cancer
Fudan University
 2025-02-12 PHASE2
NCT06447480 RECRUITING
Acne Vulgaris
Centre Hospitalier Universitaire de Nice
 2025-04-29 PHASE3
NCT06439888 RECRUITING
Oligometastatic Disease; Solid Tumor, Adult
Gustave Roussy, Cancer Campus, Grand Paris
 2024-07-11 PHASE1; PHASE2
NCT07084116 COMPLETED
Skin Tear; Solar Purpura; Dermatoporosis
James Thomas Pathoulas
 2025-07-14 PHASE2; PHASE3
NCT03031249 ENROLLING_BY_INVITATION
AML
Institute of Hematology & Blood Diseases Hospital, China
 2017-02-08 PHASE1; PHASE2
NCT06371274 RECRUITING
Triple-negative Breast Cancer
First Affiliated Hospital of Zhejiang University
 2024-10-10
NCT07366229 RECRUITING
Acne
Shenzhen People's Hospital
 2025-12-30 PHASE2
NCT03611595 COMPLETED
Solid Tumor
Peter Zage
 2018-08-28 PHASE1
NCT05881265 RECRUITING
APL
Shanghai Jiao Tong University School of Medicine
 2023-05-15 PHASE2
NCT07142070 NOT_YET_RECRUITING
Periodontal Diseases; Inflammation
Medipol University
 2025-09-01
NCT06158412 RECRUITING
Multiple Myeloma in Relapse; Multiple Myeloma, Refractory
The First Affiliated Hospital of Xiamen University
 2023-11-22 PHASE2
NCT07469228 COMPLETED
Acne Vulgaris
Sun Pharmaceutical Industries, Inc.
 2025-08-04 PHASE1
NCT07154030 NOT_YET_RECRUITING
Striae
Sohag University
 2025-09-05 PHASE1
NCT04793919 RECRUITING
Acute Promyelocytic Leukemia
Associazione Italiana Ematologia Oncologia Pediatrica
 2019-10-09 PHASE2
NCT06020833 WITHDRAWN
Myelodysplastic Syndromes
Peking Union Medical College Hospital
 2023-08 PHASE1; PHASE2
NCT04919369 COMPLETED
Metastatic Lung Non-Small Cell Carcinoma; Recurrent Lung Non-Small Cell Carcinoma; Stage IV Lung Cancer AJCC v8; Stage IVA Lung Cancer AJCC v8; Stage IVB Lung Cancer AJCC v8
Dwight Owen
 2021-10-18 PHASE1
NCT07345507 COMPLETED
Melasma
Jinnah Postgraduate Medical Centre
 2025-02-01
NCT06787222 ACTIVE_NOT_RECRUITING
Acne Vulgaris
Hasanuddin University
 2024-11-03 PHASE2; PHASE3
NCT07675460 COMPLETED
Dry Eye; Choroidal Thickness; Retinal Vascularisation; Acne Cystic; Isotretinoin
Demet Mutlu
 2024-04-01
NCT05497310 UNKNOWN
Promyelocytic Leukemia
Hospital Universitario Dr. Jose E. Gonzalez
 2022-07-01 PHASE1; PHASE2
NCT06780644 NOT_YET_RECRUITING
Melasma
Indonesia University
 2025-02-17
NCT07012811 COMPLETED
Plane Warts
Latakia University
 2024-02-12 PHASE4
NCT07015931 COMPLETED
Acne Vulgaris
Indonesia University
 2024-11-30 PHASE1; PHASE2
NCT05482451 UNKNOWN
Effect of Drug
China Medical University Hospital
 2021-03-01 EARLY_PHASE1
NCT04113863 TERMINATED
Breast Neoplasm Female
Mario Negri Institute for Pharmacological Research
 2019-06-18 PHASE2
NCT06571721 UNKNOWN
Collagen Degeneration; Wrinkle; Pigmentation; Elastic Skin; Sebum Deficiency
Integrative Skin Science and Research
 2024-07-22
NCT02688140 COMPLETED
Acute Promyelocytic Leukemia
Technische Universität Dresden
 2016-06 PHASE3
NCT06242288 COMPLETED
Acne Vulgaris
Mostafa Bahaa
 2024-01-30 PHASE3
NCT05438875 COMPLETED
Purpura, Thrombocytopenic, Idiopathic
Peking University People's Hospital
 2022-10-12 PHASE3
NCT03491267 COMPLETED
Central Centrifugal Cicatricial Alopecia (CCCA)
Johns Hopkins University
 2018-01-01 EARLY_PHASE1
NCT05316675 UNKNOWN
Acne Vulgaris
Assiut University
 2022-12 PHASE4
NCT06213987 COMPLETED
Acanthosis Nigricans; Hyperpigmentation
Srinakharinwirot University
 2024-02-01 PHASE3
NCT04282668 TERMINATED
Acute Myeloid Leukemia
Taiho Oncology, Inc.
 2020-03-15 PHASE1
NCT06728631 ACTIVE_NOT_RECRUITING
Oral Cavity Cancer; Premalignant Lesion
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
 2020-06-30 PHASE2
NCT05297123 UNKNOWN
Acute Myeloid Leukemia
First Affiliated Hospital Xi'an Jiaotong University
 2019-02-03 PHASE1
NCT06181838 UNKNOWN
Acne Vulgaris; Quality of Life
Indonesia University
 2023-08-28
NCT04700176 TERMINATED
Multiple Myeloma
Hackensack Meridian Health
 2022-05-02 PHASE2
NCT05259722 COMPLETED
Chronic Hand Eczema
LEO Pharma
 2022-06-15 PHASE3
NCT06097546 Not yet recruiting
Breast Cancer
Assiut University
 2023-11-01 --
NCT05461755 COMPLETED
Striae Distensae
Merete Haedersdal
 2022-11-22 PHASE2
NCT04385277 ACTIVE_NOT_RECRUITING
Ganglioneuroblastoma, Nodular; Neuroblastoma
Children's Oncology Group
 2020-12-31 PHASE2
NCT05373901 COMPLETED
High-risk Neuroblastoma
BeiGene
 2022-06-07 PHASE1
NCT06008327 COMPLETED
Acanthosis Nigricans
Jinnah Postgraduate Medical Centre
 2022-08-01
NCT05281965 UNKNOWN
Autism; Treatment Adherence; Retinoic Acid; Dup15Q Syndrome
Second Affiliated Hospital, Zhejiang University, School of Medicine
 2022-04-01 EARLY_PHASE1
NCT01526603 COMPLETED
Neuroblastoma
Masonic Cancer Center, University of Minnesota
 2012-03-28
NCT04324411 WITHDRAWN
Autoimmune Anemia
Peking Union Medical College Hospital
 2020-04-20 PHASE4
NCT04940767 COMPLETED
Acne Vulgaris
Edward Lain, MD
 2021-06-28 PHASE4
NCT02807558 COMPLETED
Acute Myeloid Leukemia; Myelodysplastic Syndrome
Syros Pharmaceuticals
 2016-09-20 PHASE2
NCT00382200 COMPLETED
Myelodysplastic Syndromes
Memorial Sloan Kettering Cancer Center
 2006-07 PHASE1; PHASE2
NCT05832320 Recruiting
Acute Promyelocytic Leukemia|Induction Therapy|Oral
Peking University People''s Hospital
 2023-01-01 Not Applicable
NCT05973084 Recruiting
SARS CoV 2 Infection|SARS CoV 2 Vaccination
Boston University|National Institute of Allergy and Infectious Diseases (NIAID)|Malaria Alert Center Kamuzu University of Health Sciences|Burnet Institute
 2023-01-17 --
NCT06013540 UNKNOWN
Melasma
Jinnah Postgraduate Medical Centre
 2022-08-01 PHASE2
NCT04433169 UNKNOWN
Adenoid Cystic Carcinoma of the Head and Neck
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
 2020-06-03 PHASE2
NCT02751255 COMPLETED
Multiple Myeloma
Amsterdam UMC, location VUmc
 2016-07-06 PHASE1; PHASE2
NCT02279095 COMPLETED
Fibrodysplasia Ossificans Progressiva
Clementia Pharmaceuticals Inc.
 2014-10-09 PHASE2
NCT02899169 UNKNOWN
Acute Promyelocytic Leukemia
First Affiliated Hospital Xi'an Jiaotong University
 2016-09-01 PHASE3
NCT03200847 COMPLETED
Stage IV Melanoma; Stage III Melanoma; Advanced Melanoma
University of Colorado, Denver
 2017-10-31 PHASE1; PHASE2
NCT03026946 UNKNOWN
Hand Eczema
University Medical Center Groningen
 2017-05-29 PHASE3
NCT03572387 COMPLETED
Prostatic Neoplasms; Prostate Neoplasms; Prostate Cancer
Icahn School of Medicine at Mount Sinai
 2018-08-20 PHASE2
NCT05175508 UNKNOWN
AML; MDS; Old Age; Debility; Hematologic Cancer
The First Affiliated Hospital of Soochow University
 2021-05-01 PHASE2; PHASE3
NCT02712905 TERMINATED
Solid Tumors and Hematologic Malignancy
Incyte Corporation
 2016-05-05 PHASE1; PHASE2
NCT05077813 UNKNOWN
Tuberculosis
Kafrelsheikh University
 2021-12 PHASE2
NCT03786783 COMPLETED
Ganglioneuroblastoma; High Risk Neuroblastoma
National Cancer Institute (NCI)
 2019-03-04 PHASE2
NCT05004909 UNKNOWN
Photoaging
Dr.dr.Irma Bernadette, SpKK (K)
 2021-09-01
NCT03574701 UNKNOWN
Olfactory Disorder
St. Paul's Hospital, Canada
 2016-05-25
NCT05002530 UNKNOWN
Post COVID-19 Anosmia (Loss of Smell)
Kafrelsheikh University
 2021-11 PHASE4
NCT01857934 COMPLETED
Neuroblastoma
St. Jude Children's Research Hospital
 2013-07-05 PHASE2
NCT04353180 UNKNOWN
COVID19
Kafrelsheikh University
 2021-08 PHASE3
NCT04389580 UNKNOWN
COVID-19
Kafrelsheikh University
 2021-09 PHASE2
NCT05016349 UNKNOWN
Breast Cancer Female
Mahmoud Ramadan mohamed Elkazzaz
 2021-08 PHASE3
NCT04618328 UNKNOWN
Immune Thrombocytopenia
Peking University People's Hospital
 2020-11 PHASE2
NCT04730895 UNKNOWN
Covid19 Vaccine
Kafrelsheikh University
 2021-07 PHASE1; PHASE2
NCT04175587 UNKNOWN
Acute Promyelocytic Leukaemia
Peking University People's Hospital
 2019-12-01 PHASE3
NCT04361422 UNKNOWN
COVID-19
Tanta University
 2020-12-01 PHASE3
NCT04382950 UNKNOWN
COVID
Kafrelsheikh University
 2021-07 PHASE1
NCT04096742 UNKNOWN
Photodamaged Skin; Photoaging
Goldman, Butterwick, Fitzpatrick and Groff
 2019-08-06 PHASE4
NCT04883736 COMPLETED
Acne Vulgaris
Sun Pharmaceutical Industries, Inc.
 2020-08-31 EARLY_PHASE1
NCT01404949 COMPLETED
Acute Promyelocytic Leukemia
Memorial Sloan Kettering Cancer Center
 2011-07 PHASE2
NCT03304288 UNKNOWN
Immune Thrombocytopenia
Peking University People's Hospital
 2017-10-11 PHASE2
NCT01987297 UNKNOWN
Acute Promyelocytic Leukemia
Shanghai Jiao Tong University School of Medicine
 2012-06 PHASE4
NCT03878524 TERMINATED
Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Anatomic Stage IV Breast Cancer AJCC v8; Anemia; Ann Arbor Stage III Hodgkin Lymphoma; Ann Arbor Stage III Non-Hodgkin Lymphoma; Ann Arbor Stage IV Hodgkin Lymphoma; Ann Arbor Stage IV Non-Hodgkin Lymphoma; Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative; Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Castration-Resistant Prostate Carcinoma; Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Hematopoietic and Lymphoid System Neoplasm; Locally Advanced Pancreatic Adenocarcinoma; Metastatic Breast Carcinoma; Metastatic Malignant Solid Neoplasm; Metastatic Pancreatic Adenocarcinoma; Myelodysplastic/Myeloproliferative Neoplasm With Ring Sideroblasts and Thrombocytosis; Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable; Primary Myelofibrosis; Recurrent Acute Lymphoblastic Leukemia; Recurrent Acute Myeloid Leukemia; Recurrent Chronic Lymphocytic Leukemia; Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Recurrent Hematologic Malignancy; Recurrent Hodgkin Lymphoma; Recurrent Myelodysplastic Syndrome; Recurrent Myelodysplastic/Myeloproliferative Neoplasm; Recurrent Myeloproliferative Neoplasm; Recurrent Non-Hodgkin Lymphoma; Recurrent Plasma Cell Myeloma; Recurrent Small Lymphocytic Lymphoma; Refractory Acute Lymphoblastic Leukemia; Refractory Acute Myeloid Leukemia; Refractory Chronic Lymphocytic Leukemia; Refractory Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Refractory Chronic Myelomonocytic Leukemia; Refractory Hematologic Malignancy; Refractory Hodgkin Lymphoma; Refractory Malignant Solid Neoplasm; Refractory Myelodysplastic Syndrome; Refractory Myelodysplastic/Myeloproliferative Neoplasm; Refractory Non-Hodgkin Lymphoma; Refractory Plasma Cell Myeloma; Refractory Primary Myelofibrosis; Refractory Small Lymphocytic Lymphoma; Stage II Pancreatic Cancer AJCC v8; Stage III Pancreatic Cancer AJCC v8; Stage IV Pancreatic Cancer AJCC v8; Stage IV Prostate Cancer AJCC v8; Unresectable Pancreatic Adenocarcinoma
OHSU Knight Cancer Institute
 2020-04-01 PHASE1
NCT03359174 TERMINATED
Cholangitis, Sclerosing
Yale University
 2018-05-29 PHASE2
NCT01701479 UNKNOWN
Neuroblastoma
St. Anna Kinderkrebsforschung
 2012-01 PHASE1; PHASE2
NCT02717884 UNKNOWN
Acute Myeloid Leukemia; Myelodysplastic Syndrome
Michael Luebbert
 2015-05 PHASE1; PHASE2
NCT04568096 UNKNOWN
the Lung Complication of COVID-19
Kafrelsheikh University
 2020-11 PHASE2
NCT04578236 UNKNOWN
Covid19
Kafrelsheikh University
 2020-11 PHASE2
NCT04623385 UNKNOWN
Covid19
Kafrelsheikh University
 2020-11 PHASE4
NCT01064557 UNKNOWN
Leukemia
Gruppo Italiano Malattie EMatologiche dell'Adulto
 1993-10
NCT04724473 COMPLETED
Acne Vulgaris
Sun Pharmaceutical Industries, Inc.
 2019-12-10 EARLY_PHASE1
NCT04577378 UNKNOWN
Covid19
Kafrelsheikh University
 2020-10-20 PHASE2
NCT02339740 ACTIVE_NOT_RECRUITING
Acute Promyelocytic Leukemia With t(15;17)(q24.1;q21.2); PML-RARA
Children's Oncology Group
 2015-07-21 PHASE3
NCT04396067 UNKNOWN
COVID-19
Kafrelsheikh University
 2020-10 PHASE2
NCT04080869 COMPLETED
Facial Acne Vulgaris
Assiut University
 2020-01-06 PHASE2
NCT04217148 COMPLETED
Immune Thrombocytopenia
Peking University People's Hospital
 2020-01-01 PHASE2
NCT03999684 COMPLETED
Adenoid Cystic Carcinoma
Dana-Farber Cancer Institute
 2019-08-05 PHASE2
NCT00867178 COMPLETED
Medulloblastoma; Pineoblastoma; Supratentorial Embryonal Tumor, Not Otherwise Specified
National Cancer Institute (NCI)
 2009-02-25 PHASE1
NCT00555399 TERMINATED
Glioblastoma Multiforme; Anaplastic Glioma
M.D. Anderson Cancer Center
 2007-11-28 PHASE1; PHASE2
NCT03026907 UNKNOWN
Hand Eczema
University Medical Center Groningen
 2016-05 PHASE3
NCT03933774 COMPLETED
Vitiligo
The Catholic University of Korea
 2019-04-29
NCT04417348 COMPLETED
Melasma
Universidad Autonoma de San Luis Potosí
 2019-01-31
NCT03291080 COMPLETED
Neuroblastoma
Nova Laboratories Limited
 2018-04-17 PHASE1; PHASE2
NCT00392327 COMPLETED
Anaplastic Medulloblastoma; Medulloblastoma
Children's Oncology Group
 2007-05-23 PHASE3
NCT03323801 COMPLETED
Male Infertility, Azoospermia
University of Washington
 2017-07-25 PHASE2
NCT03753867 WITHDRAWN
HIV Infections
Ottawa Hospital Research Institute
 2019-01-07 PHASE1
NCT03259516 TERMINATED
Myelodysplastic Syndromes
St. Petersburg State Pavlov Medical University
 2017-05-25 PHASE1; PHASE2
NCT02061384 COMPLETED
Male Infertility; Klinefelter's Syndrome; Y-chromosome Microdeletions
University of Washington
 2014-08 PHASE2
NCT01183884 TERMINATED
Neuroblastoma
Memorial Sloan Kettering Cancer Center
 2010-08 PHASE2
NCT02273102 COMPLETED
Acute Myelogenous Leukemia; Myelodysplastic Syndromes; Leukemia
University of Miami
 2015-03-02 PHASE1
NCT01183416 COMPLETED
Neuroblastoma
Memorial Sloan Kettering Cancer Center
 2010-08 PHASE2
NCT02842827 COMPLETED
Acute Myeloid Leukemia; Myelodysplastic Syndrome
Imago BioSciences, Inc., a subsidiary of Merck & Co., Inc., (Rahway, New Jersey USA)
 2016-10-06 PHASE1; PHASE2
NCT01183897 COMPLETED
Neuroblastoma
Memorial Sloan Kettering Cancer Center
 2010-08-12 PHASE2
NCT01711554 ACTIVE_NOT_RECRUITING
Recurrent Neuroblastoma; Refractory Neuroblastoma
National Cancer Institute (NCI)
 2013-02-04 PHASE1
NCT01183429 COMPLETED
Neuroblastoma
Memorial Sloan Kettering Cancer Center
 2010-08-12 PHASE2
NCT02403778 COMPLETED
Melanoma
University of Colorado, Denver
 2015-12-17 PHASE2
NCT01237808 COMPLETED
Acute Myeloid Leukemia (AML)
University of Ulm
 2011-03 PHASE3
NCT00334789 COMPLETED
Adult Solid Neoplasm
National Cancer Institute (NCI)
 2006-06-12 PHASE1
NCT03433378 COMPLETED
Acne Vulgaris
Sun Pharmaceutical Industries, Inc.
 2017-08-04 EARLY_PHASE1
NCT03427554 COMPLETED
Acne Vulgaris
Sun Pharmaceutical Industries, Inc.
 2017-08-21 EARLY_PHASE1
NCT02620813 COMPLETED
Acne Vulgaris
University of California, Davis
 2015-10 EARLY_PHASE1
NCT02261779 UNKNOWN
AML
Martin-Luther-Universität Halle-Wittenberg
 2014-09 PHASE1; PHASE2
NCT00528437 COMPLETED
Brain Tumors
NYU Langone Health
 2005-10 PHASE2
NCT00551460 COMPLETED
Leukemia
SWOG Cancer Research Network
 2007-11-15 PHASE2
NCT00200161 COMPLETED
Glioblastoma; Gliomas
Memorial Sloan Kettering Cancer Center
 2005-08-09 PHASE2
NCT02731105 COMPLETED
Acne Vulgaris
GWT-TUD GmbH
 2015-02 PHASE4
NCT03042429 COMPLETED
Neuroblastoma
University of Cologne
 2007-01-01 PHASE3
NCT02641782 TERMINATED
Neuroblastoma
University of Cologne
 2015-11 PHASE2
NCT02410980 COMPLETED
Collagen Fibril Alteration
University of California, Irvine
 2015-08 EARLY_PHASE1
NCT01175356 COMPLETED
Ganglioneuroblastoma; Localized Resectable Neuroblastoma; Localized Unresectable Neuroblastoma; Regional Neuroblastoma; Stage 4 Neuroblastoma; Stage 4S Neuroblastoma
Children's Oncology Group
 2011-12-21 PHASE1
NCT01969058 COMPLETED
HIV-1 Infection
Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
 2014-07-02 PHASE2
NCT01667263 COMPLETED
Autoimmune Thrombocytopenia
Peking University People's Hospital
 2012-06-01 PHASE2
NCT01067274 WITHDRAWN
Acute Myeloid Leukemia
Acute Leukemia French Association
 2010-04 PHASE3
NCT00413166 COMPLETED
Acute Promyelocytic Leukemia
M.D. Anderson Cancer Center
 2006-12 PHASE2
NCT03392623 COMPLETED
Melasma
Universidad Autonoma de San Luis Potosí
 2015-01-01 EARLY_PHASE1
NCT02704507 UNKNOWN
Acne
Carilion Clinic
 2015-06
NCT00892190 COMPLETED
Acute Myelogenous Leukemia; Myelodysplastic Syndrome
University of Pittsburgh
 2011-04 PHASE1
NCT01406080 COMPLETED
Photoaging; Photodamage
Galderma Brasil Ltda.
 2013-01 PHASE3
NCT01820624 COMPLETED
Adult Acute Megakaryoblastic Leukemia (M7); Adult Acute Monoblastic Leukemia (M5a); Adult Acute Monocytic Leukemia (M5b); Adult Acute Myeloblastic Leukemia With Maturation (M2); Adult Acute Myeloblastic Leukemia Without Maturation (M1); Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Acute Myelomonocytic Leukemia (M4); Adult Erythroleukemia (M6a); Adult Pure Erythroid Leukemia (M6b); Recurrent Adult Acute Myeloid Leukemia
Paolo Caimi, MD
 2013-04-30 PHASE1
NCT00617409 COMPLETED
Small Cell Lung Cancer
H. Lee Moffitt Cancer Center and Research Institute
 2007-10-02 PHASE2
NCT01985477 TERMINATED
Myeloma
M.D. Anderson Cancer Center
 2013-12 PHASE1
NCT01276730 COMPLETED
Cervical Cancer
University of Louisville
 2007-10 PHASE2
NCT00866918 COMPLETED
Childhood Acute Promyelocytic Leukemia With PML-RARA; Myeloid Neoplasm
Children's Oncology Group
 2009-03-09 PHASE3
NCT02497833 COMPLETED
Hypercholesterolemia
Sun Yat-sen University
 2014-11 EARLY_PHASE1
NCT00567567 COMPLETED
Localized Resectable Neuroblastoma; Localized Unresectable Neuroblastoma; Recurrent Neuroblastoma; Regional Neuroblastoma; Stage 4 Neuroblastoma; Stage 4S Neuroblastoma
Children's Oncology Group
 2007-11-05 PHASE3
NCT00867672 COMPLETED
Acute Myeloid Leukemia
University Hospital Freiburg
 2011-08 PHASE2
NCT01882127 WITHDRAWN
Purpura; Idiopathic Thrombocytopenic Purpura
Shandong University
 2013-02 PHASE3
NCT01208454 COMPLETED
Localized Unresectable Neuroblastoma; Recurrent Neuroblastoma; Regional Neuroblastoma; Stage 4 Neuroblastoma; Stage 4S Neuroblastoma
National Cancer Institute (NCI)
 2010-12 PHASE1
NCT00112502 COMPLETED
Brain and Central Nervous System Tumors; Glioblastoma Multiforme
M.D. Anderson Cancer Center
 2005-09 PHASE2
NCT00499616 COMPLETED
Neuroblastoma
Children's Oncology Group
 2007-10-08 PHASE3
NCT01592045 COMPLETED
Neuroblastoma
United Therapeutics
 2012-08 PHASE1; PHASE2
NCT02249767 COMPLETED
Acne
Spear Pharmaceuticals
 2013-11 PHASE3
NCT01456468 COMPLETED
Cholangitis, Sclerosing
Yale University
 2011-10 PHASE1
NCT02278861 COMPLETED
Actinic Keratosis
Universidade Federal de Goias
 2011-11 PHASE2
NCT01407679 TERMINATED
Lupus Erythematosus, Cutaneous
University Hospital Muenster
 2011-08 PHASE2
NCT01245140 COMPLETED
Psoriasis
Stiefel, a GSK Company
 2011-04-26 PHASE2
NCT01349556 WITHDRAWN
Medication Reaction
Johns Hopkins University
 2011-05
NCT01538732 UNKNOWN
Lichen Planus (LP)
University of Zurich
 2012-03 PHASE2
NCT01041638 COMPLETED
High Risk Neuroblastoma
National Cancer Institute (NCI)
 2009-12-21 PHASE3
NCT00492856 COMPLETED
Leukemia
SWOG Cancer Research Network
 2007-06-01 PHASE3
NCT01275274 WITHDRAWN
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
University of North Carolina, Chapel Hill
 2012-01 PHASE2
NCT01916187 WITHDRAWN
Neuroblastoma
NCIC Clinical Trials Group
 2013-07-30 PHASE1
NCT01048086 WITHDRAWN
Neuroblastoma; Neuroendocrine Tumor
University of Iowa
 2009-06 PHASE2
NCT00995332 COMPLETED
Acute Myelogenous Leukemia
University of Bergen
 2009-09 PHASE1; PHASE2
NCT01103375 TERMINATED
Adult Anaplastic Astrocytoma; Adult Anaplastic Oligodendroglioma; Adult Diffuse Astrocytoma; Adult Giant Cell Glioblastoma; Adult Glioblastoma; Adult Gliosarcoma; Adult Mixed Glioma; Adult Oligodendroglioma; Recurrent Adult Brain Tumor
Wake Forest University Health Sciences
 2010-05 PHASE1
NCT00482833 COMPLETED
Leukemia
Gruppo Italiano Malattie EMatologiche dell'Adulto
 2007-08 PHASE3
NCT00601796 COMPLETED
Lung Cancer
H. Lee Moffitt Cancer Center and Research Institute
 2006-10 PHASE2
NCT01522456 COMPLETED
Acne Vulgaris
Galderma R&D
 2012-04 PHASE4
NCT00817063 COMPLETED
Eczema
Stiefel, a GSK Company
 2009-01-08 PHASE3
NCT01231854 TERMINATED
Atopic Dermatitis
Technische Universität Dresden
 2010-11 PHASE4
NCT00026312 COMPLETED
Localized Resectable Neuroblastoma; Localized Unresectable Neuroblastoma; Recurrent Neuroblastoma; Regional Neuroblastoma; Stage 4 Neuroblastoma; Stage 4S Neuroblastoma
National Cancer Institute (NCI)
 2001-10-26 PHASE3
NCT00514293 UNKNOWN
Lung Cancer
Raghu Nandan, M.D., Inc
 2007-01 PHASE2
NCT01283464 COMPLETED
Photodamaged Skin; Wrinkles
Johns Hopkins University
 2010-11 PHASE2
NCT01149876 COMPLETED
Hyperpigmentation
Massachusetts General Hospital
 2010-06 PHASE4
NCT01422785 UNKNOWN
Acne Vulgaris
Zeichner, Joshua, M.D.
 2011-07 PHASE4
NCT01448733 UNKNOWN
Acne Vulgaris
Zeichner, Joshua, M.D.
 2011-07 PHASE4
NCT01041833 UNKNOWN
Non Small Cell Lung Cancer
National Institute of Cancerología
 2010-01 PHASE3
NCT01161550 COMPLETED
Leukemia, Myeloid, Acute
Washington University School of Medicine
 2010-11 PHASE1
NCT00151242 COMPLETED
Acute Myeloid Leukemia
University of Ulm
 2004-07 PHASE2; PHASE3
NCT01261923 COMPLETED
Hepatic Insufficiency
University Hospital, Gentofte, Copenhagen
 2010-12 PHASE1; PHASE2
NCT01020539 COMPLETED
Acute Myelogenous Leukemia; Myelodysplastic Syndrome; Juvenile Myelomonocytic Leukemia
Columbia University
 2002-09-11 PHASE1
NCT01206348 COMPLETED
Acne
Medicis Global Service Corporation
 2010-09 PHASE4
NCT00062010 COMPLETED
Lung Cancer
Eastern Cooperative Oncology Group
 2004-05-26 PHASE2
NCT00324740 TERMINATED
Recurrent Renal Cell Cancer; Stage III Renal Cell Cancer; Stage IV Renal Cell Cancer
National Cancer Institute (NCI)
 2006-03 PHASE1; PHASE2
NCT00533169 TERMINATED
Neuroblastoma
M.D. Anderson Cancer Center
 2007-09 PHASE1
NCT00528450 TERMINATED
Leukemia
Memorial Sloan Kettering Cancer Center
 2007-09 PHASE2
NCT01313728 COMPLETED
Acne Vulgaris
Bausch Health Americas, Inc.
 2010-12 PHASE4
NCT00939133 COMPLETED
Acne
Dermatrials Research
 2009-07 PHASE4
NCT01404130 COMPLETED
Acne Vulgaris
University of Aberdeen
 2008-09 PHASE4
NCT00138151 TERMINATED
Cervical Cancer
University of Medicine and Dentistry of New Jersey
 2001-03 PHASE2
NCT01243450 COMPLETED
Acne
Spear Pharmaceuticals
 2009-10 PHASE3
NCT00823901 COMPLETED
Rosacea
Massachusetts General Hospital
 2009-02 PHASE2; PHASE3
NCT01257906 COMPLETED
MILD TO SEVERE ACNE VULGARIS
Actavis Mid-Atlantic LLC
 2010-05
NCT01027793 COMPLETED
Stretch Marks; Striae; Treatment
Hexsel Dermatology Clinic
 2009-03 PHASE4
NCT00969722 TERMINATED
Primary Refractory Neuroblastoma
United Therapeutics
 2009-08 PHASE2
NCT00974480 COMPLETED
Skin Aging
Cosmetique Active International
 2009-09
NCT00609739 TERMINATED
Leukemia
Masonic Cancer Center, University of Minnesota
 1999-06 PHASE1; PHASE2
NCT01135069 COMPLETED
Acne
Spear Pharmaceuticals
 2009-10 PHASE3
NCT01111994 UNKNOWN
Acne
Callender Center for Clinical Research
 2009-11 PHASE4
NCT00647556 COMPLETED
Photoaging
Galderma R&D
 2008-04 PHASE3
NCT00838812 COMPLETED
Acne Vulgaris
Igefarma Laboratorios S.A.
 2009-03 PHASE3
NCT00842907 UNKNOWN
Photodamage; Photoaging
Federal University of São Paulo
 2009-05 PHASE2
NCT00919555 COMPLETED
Amyotrophic Lateral Sclerosis
Phoenix Neurological Associates, LTD
 2008-06 PHASE1; PHASE2
NCT00952523 COMPLETED
Acne Vulgaris
Bausch Health Americas, Inc.
 2009-07 PHASE4
NCT01047189 COMPLETED
Acne Vulgaris
Wake Forest University
 2009-03 PHASE4
NCT00907257 COMPLETED
Acne Vulgaris
Bausch Health Americas, Inc.
 2009-02 PHASE4
NCT00217412 COMPLETED
Childhood Acute Promyelocytic Leukemia (M3); Childhood Atypical Teratoid/Rhabdoid Tumor; Childhood Burkitt Lymphoma; Childhood Chronic Myelogenous Leukemia; Childhood Diffuse Large Cell Lymphoma; Childhood Immunoblastic Large Cell Lymphoma; Juvenile Myelomonocytic Leukemia; Recurrent Childhood Acute Lymphoblastic Leukemia; Recurrent Childhood Acute Myeloid Leukemia; Recurrent Childhood Grade III Lymphomatoid Granulomatosis; Recurrent Childhood Large Cell Lymphoma; Recurrent Childhood Lymphoblastic Lymphoma; Recurrent Childhood Medulloblastoma; Recurrent Childhood Small Noncleaved Cell Lymphoma; Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor; Recurrent Neuroblastoma; Recurrent/Refractory Childhood Hodgkin Lymphoma; Relapsing Chronic Myelogenous Leukemia; Unspecified Childhood Solid Tumor, Protocol Specific
National Cancer Institute (NCI)
 2005-08 PHASE1
NCT00835198 COMPLETED
Acne Vulgaris
Allergan
 2008-12 PHASE4
NCT00808899 TERMINATED
Neuroblastoma
St. Jude Children's Research Hospital
 2008-12 PHASE2
NCT00891982 COMPLETED
Acne Vulgaris
Stiefel, a GSK Company
 2009-04-01 PHASE3
NCT00151255 COMPLETED
Acute Myeloid Leukemia
University of Ulm
 2004-06 PHASE3
NCT00919191 COMPLETED
Acne Vulgaris
Bausch Health Americas, Inc.
 2009-04 PHASE4
NCT00689117 COMPLETED
Acne Vulgaris; Acne
Stiefel, a GSK Company
 2008-04 PHASE3
NCT01915758 COMPLETED
Acne Vulgaris
GlaxoSmithKline
 2008-11-21 PHASE1
NCT01929278 COMPLETED
Acne Vulgaris
Stiefel, a GSK Company
 2008-12-08 PHASE1
NCT01048645 COMPLETED
Non-Small-Cell Lung Carcinoma
National Institute of Cancerología
 2007-09 PHASE2
NCT00975312 COMPLETED
Lentigo
Pontificia Universidad Catolica de Chile
 2008-08 PHASE2
NCT00669071 TERMINATED
Melasma
Galderma R&D
 2008-01 PHASE4
NCT00339196 COMPLETED
Acute Myelogenous Leukaemia (AML); Myelodysplastic Syndrome (MDS)
Assistance Publique - Hôpitaux de Paris
 2006-07 PHASE2
NCT00717652 SUSPENDED
Melasma
Azidus Brasil
 2008-07 PHASE2; PHASE3
NCT00003656 COMPLETED
Kidney Cancer
Weill Medical College of Cornell University
 1999-01 PHASE2
NCT00175812 COMPLETED
Acute Myelogenous Leukemia
University of Bergen
 2004-11 PHASE1; PHASE2
NCT00621218 COMPLETED
Rosacea
Coria Laboratories, Ltd.
 2008-02 PHASE2
NCT00603772 COMPLETED
Healthy
Coria Laboratories, Ltd.
 2008-01 PHASE1
NCT00098891 COMPLETED
Adult Grade III Lymphomatoid Granulomatosis; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Primary Central Nervous System Non-Hodgkin Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Mixed Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Hodgkin Lymphoma; Stage IV Adult Immunoblastic Large Cell Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Adult T-cell Leukemia/Lymphoma; Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Mycosis Fungoides/Sezary Syndrome; Stage IV Small Lymphocytic Lymphoma; Unspecified Adult Solid Tumor, Protocol Specific; Waldenström Macroglobulinemia
National Cancer Institute (NCI)
 2004-10 PHASE1
NCT00714714 COMPLETED
Acne Vulgaris
Bausch Health Americas, Inc.
 2008-01 PHASE4
NCT00604032 COMPLETED
Healthy
Coria Laboratories, Ltd.
 2008-01 PHASE1
NCT00276601 COMPLETED
Leukemia
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
 2004-10 PHASE2
NCT00004188 COMPLETED
Neuroblastoma
Children's Oncology Group
 2001-02 PHASE3
NCT00025038 COMPLETED
Juvenile Myelomonocytic Leukemia
National Cancer Institute (NCI)
 2001-06 PHASE2
NCT00176527 TERMINATED
Prostate Cancer
University of Medicine and Dentistry of New Jersey
 2002-11 PHASE2
NCT00326170 COMPLETED
Myelodysplastic Syndrome; Acute Myelogenous Leukemia
M.D. Anderson Cancer Center
 2005-07 PHASE2
NCT00143975 COMPLETED
Leukemia, Myeloid, Acute
University of Ulm
 2004-06 PHASE2
NCT00135135 COMPLETED
Neuroblastoma
St. Jude Children's Research Hospital
 2005-08 PHASE2
NCT00469183 COMPLETED
Melasma
Galderma R&D
 2006-05 PHASE4
NCT00472966 COMPLETED
Melasma
Galderma R&D
 2006-11 PHASE4
NCT00309621 COMPLETED
Hand Dermatoses
Basilea Pharmaceutica
 2006-04 PHASE3
NCT00016159 COMPLETED
Leukemia
Memorial Sloan Kettering Cancer Center
 2000-11 PHASE2
NCT00124436 COMPLETED
Hand Dermatoses
Basilea Pharmaceutica
 2005-03 PHASE3
NCT00240513 TERMINATED
Acne Vulgaris
Derm Research @ 888 Inc.
 2004-08 PHASE4
NCT00003934 COMPLETED
Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Promyelocytic Leukemia (M3); Childhood Acute Promyelocytic Leukemia (M3); Untreated Adult Acute Myeloid Leukemia; Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies
National Cancer Institute (NCI)
 1999-06 PHASE3
NCT00124475 COMPLETED
Hand Dermatoses
Basilea Pharmaceutica
 2004-12 PHASE3
NCT00078988 COMPLETED
Brain Tumor; Central Nervous System Tumor
Children's Oncology Group
 2004-10 PHASE3
NCT00002586 COMPLETED
Drug Toxicity; Lung Cancer
University of Colorado, Denver
 1993-01 PHASE2
NCT00038376 COMPLETED
Lymphoma, T-Cell; Mycosis Fungoides; Hematologic Neoplasms
M.D. Anderson Cancer Center
 1990-05-08 PHASE2
NCT00006239 COMPLETED
Leukemia; Myelodysplastic Syndromes; Myelodysplastic/Myeloproliferative Diseases
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
 2000-12 PHASE1
NCT00000621 COMPLETED
Emphysema; Lung Diseases; Lung Diseases, Obstructive; Chronic Obstructive Pulmonary Disease
National Heart, Lung, and Blood Institute (NHLBI)
 1999-09 PHASE2
NCT00007631 COMPLETED
Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Skin Neoplasms
US Department of Veterans Affairs
 1998-03 PHASE3
NCT00005847 COMPLETED
Prostate Cancer
Eastern Cooperative Oncology Group
 2001-04-05 PHASE2
NCT00002479 COMPLETED
Lymphoma
Northwestern University
 1991-10 PHASE2
NCT00003598 COMPLETED
Cervical Cancer; Precancerous/Nonmalignant Condition
University of Michigan Rogel Cancer Center
 1999-01
NCT00005969 WITHDRAWN
Lymphoma
M.D. Anderson Cancer Center
 1999-09 PHASE2
NCT00002737 COMPLETED
Kidney Cancer
European Organisation for Research and Treatment of Cancer - EORTC
 1996-03 PHASE3
NCT00006220 TERMINATED
Leukemia; Lymphoma; Multiple Myeloma and Plasma Cell Neoplasm; Myelodysplastic Syndromes
Washington University School of Medicine
 1999-06 PHASE1; PHASE2
NCT00136461 COMPLETED
Acute Myelogenous Leukemia; Myelodysplastic Syndrome
Dana-Farber Cancer Institute
 1997-05 PHASE2
NCT00021359 COMPLETED
Multiple Myeloma and Plasma Cell Neoplasm
Fox Chase Cancer Center
 1999-08 PHASE2
NCT00003601 COMPLETED
Melanoma (Skin)
Eastern Cooperative Oncology Group
 1999-02-23 PHASE2
NCT00003405 WITHDRAWN
Leukemia
Rush University Medical Center
 1998-04 PHASE2
NCT03370367 COMPLETED
Stage I-II Head and Neck Cancer
Eastern Cooperative Oncology Group
 1989-05-15 PHASE3
NCT00002506 COMPLETED
Cervical Cancer; Esophageal Cancer; Head and Neck Cancer; Lung Cancer; Non-melanomatous Skin Cancer; Penile Cancer
Hoag Memorial Hospital Presbyterian
 1992-08 PHASE2
NCT00437450 UNKNOWN
Anemia in Myelodysplastic Syndromes
Groupe Francophone des Myelodysplasies
 2004-10 PHASE2
NCT00001438 COMPLETED
HIV Infections; Immunologic Deficiency Syndromes; Lymphoproliferative Disorders
National Cancer Institute (NCI)
 1995-06 PHASE2
NCT00005823 COMPLETED
Leukemia; Myelodysplastic Syndromes; Myelodysplastic/Myeloproliferative Neoplasms
Leukemia Research Fund
 1998-12 PHASE3
NCT00002188 COMPLETED
Sarcoma, Kaposi; HIV Infections
Anderson Clinical Research
 PHASE2
NCT00519675 COMPLETED
Eczema
Basilea Pharmaceutica
 2007-05 PHASE3
NCT00017225 COMPLETED
Neuroblastoma
German Society for Pediatric Oncology and Hematology GPOH gGmbH
 1997-05 PHASE2
NCT00002701 UNKNOWN
Leukemia
European Organisation for Research and Treatment of Cancer - EORTC
 1995-10 PHASE3
NCT00156169 COMPLETED
Low HDL Cholesterol
Sheba Medical Center
 2001-05 PHASE3
NCT00001504 COMPLETED
Breast Cancer; Breast Neoplasm
National Cancer Institute (NCI)
 1996-05 PHASE1
NCT00005863 COMPLETED
Leukemia; Myelodysplastic Syndromes; Myelodysplastic/Myeloproliferative Neoplasms
Medical Research Council
 1998-08 PHASE3
NCT00005825 UNKNOWN
Lung Cancer
Raghu Nandan, M.D., Inc
 1998-09 PHASE2
NCT00002658 UNKNOWN
Leukemia; Neutropenia
Medical Research Council
 1994-01 PHASE3
NCT00002439 COMPLETED
Sarcoma, Kaposi; HIV Infections
Anderson Clinical Research
NCT00003564 WITHDRAWN
Brain and Central Nervous System Tumors
M.D. Anderson Cancer Center
 PHASE3
NCT00003599 WITHDRAWN
Lung Cancer
M.D. Anderson Cancer Center
 PHASE3
NCT00003619 COMPLETED
Chronic Myeloproliferative Disorders; Leukemia; Myelodysplastic Syndromes; Thrombocytopenia
Drexel University College of Medicine
 1998-02 PHASE1; PHASE2
NCT01064570 UNKNOWN
Acute Promyelocytic Leukemia
Gruppo Italiano Malattie EMatologiche dell'Adulto
 2000-05 PHASE2
NCT00939965 UNKNOWN
Neuroblastoma
Children's Cancer and Leukaemia Group
 2009-02
NCT00001509 COMPLETED
Nephroblastoma; Neuroblastoma
National Cancer Institute (NCI)
 1996-07 PHASE2

(data from https://clinicaltrials.gov, updated on 2026-08-25)

Check the Retinoic acid (Tretinoin, Vitamin A acid) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Retinoic acid functions as a nuclear agonist that binds directly to retinoic acid receptors (RARs), relieving transcriptional repression caused by oncogenic fusion proteins like PML-RAR and triggering downstream cellular maturation pathways. This mechanistic induction of myeloid differentiation and apoptosis leads to the clearance of malignant precursor cells, directly driving clinical response in patients with acute promyelocytic leukemia and solid tumors studied across clinical trials.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

Jump to

Note: Technical data last updated: Sep 1, 2026.