CAS No. 302-79-4
Batch:
Purity:99.91
Chemical Structure
Check the
Retinoic acid (Tretinoin, Vitamin A acid)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid | |
|---|---|---|
| CAS Number | 302-79-4 | |
| Molecular Formula |
C20H28O2 |
|
| Molecular Weight (MW) | 300.4 | |
| SMILES | CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C | |
| InChIKey | SHGAZHPCJJPHSC-YCNIQYBTSA-N |
Retinoic acid (Tretinoin) is a natural retinoic acid receptor (RAR) agonist that targets the PML-RAR alpha fusion protein resulting from chromosomal translocation in acute promyelocytic leukemia. Activation of RAR signaling pathways relieves transcriptional repression, restoring cell maturation programs. This functional activation triggers granulocytic differentiation and promotes apoptotic cell death in leukemic promyelocytes. [1][2]
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
60 mg/mL
(199.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 7 mg/mL |
| Water | Insoluble |
| DMSO |
50 mg/mL
(166.44 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 10 mg/mL |
| Water | Insoluble |
| DMSO |
60 mg/mL
(199.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
| DMSO |
60 mg/mL
(199.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
| DMSO |
60 mg/mL
(199.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 4 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
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- Retinoic acid (Tretinoin, Vitamin A acid) Working Concentration | Cell Culture | Treatment
- Retinoic acid (Tretinoin, Vitamin A acid) Solubility in DMSO
- Retinoic acid (Tretinoin, Vitamin A acid) Storage
- Retinoic acid (Tretinoin, Vitamin A acid) Stability
- Retinoic acid (Tretinoin, Vitamin A acid) Combination Database
- Retinoic acid (Tretinoin, Vitamin A acid) Molecular Weight
- Retinoic acid (Tretinoin, Vitamin A acid) SMILES
- Retinoic acid (Tretinoin, Vitamin A acid) Chemical Structure (2D and 3D)
- Retinoic acid (Tretinoin, Vitamin A acid) IC50 for Cell-based and Cell-free Assays
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Note: Technical data last updated: Sep 1, 2026.