RepSox (E-616452) is a potent TGF-βR1 (ALK5) inhibitor. It affects the TGF-β/Smad signaling pathway, and by blocking Smad2/3 phosphorylation, it promotes cellular reprogramming, pluripotency, and inhibits epithelial-mesenchymal transition (EMT).
RepSox (E-616452) IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for RepSox (E-616452) Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.