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RepSox (E-616452) SDS | MSDS

1.PRODUCT AND COMPANY IDENTIFICATION

Product identifier

  • Product Name: RepSox (E-616452)
  • Catalog Number: S7223
  • CAS Number: 446859-33-2
  • IUPAC Name: 1,5-Naphthyridine, 2-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-

Relevant identified uses and uses advised against

  • Identified uses: For research and development use only; laboratory chemicals; manufacture of substances.
  • Uses advised against: Not for pharmaceutical, household, or other unapproved uses.

Details of the supplier

  • Company : Selleck Chemicals
  • TollFree : +1 877 796-6397
  • Tel : +1 832 582-8158
  • Fax : +1 832 582-8590

Emergency telephone number

  • Emergency phone #: +1 832 582-8158

2. HAZARDS IDENTIFICATION

GHS Classification:
In accordance with the OSHA Hazard Communication Standard (29 CFR 1910.1200), this product is classified as:

  • Flammable powder: Category 4

Signal Word: Warning

Hazard Statements:

  • H227: Combustible powder.

Precautionary Statements:

  • Prevention: Keep away from heat, sparks, open flames, and hot surfaces. No smoking. Wear protective gloves, eye protection, and face protection.
  • Response: In case of fire, use dry sand, dry chemical, or alcohol-resistant foam for extinction.
  • Storage: Store in a well-ventilated, cool place.
  • Disposal: Dispose of contents and container at an approved waste disposal plant.

Other Hazards: None known.

3. COMPOSITION/INFORMATION ON INGREDIENTS

This product is a mixture.
Components:

  • Dimethyl sulphoxide (CAS No. 67-68-5): Concentration is withheld as a trade secret (>= 90 - <= 100%).
  • Product Identity: 1,5-Naphthyridine, 2-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-

4. FIRST AID MEASURES

  • Inhalation: Move to fresh air.
  • Skin Contact: Immediately remove all contaminated clothing. Rinse skin with water or shower.
  • Eye Contact: Rinse thoroughly with plenty of water and remove contact lenses.
  • Ingestion: Have the victim drink a maximum of two glasses of water. Consult a physician if feeling unwell. Subsequently, administer an activated charcoal slurry (20 - 40 g in 10% slurry).
  • Most Important Symptoms: Refer to Section 2.2 and Section 11 for known symptoms and effects.
  • Protection of First-Aiders: Refer to Section 8 for personal protection.
  • Notes to Physician: A laxative such as sodium sulfate (1 tablespoon per 1/4 liter of water) may be administered.

5. FIRE-FIGHTING MEASURES

  • Suitable Extinguishing Media: Water, foam, carbon dioxide (CO2), or dry powder.
  • Unsuitable Extinguishing Media: No limitations are specified for this substance.
  • Specific Hazards: The product is combustible. Powder particles are heavier than air and may spread along floors. Intense heating may lead to the formation of explosive mixtures with air. Fire may evolve hazardous combustion gases including sulfur oxides, carbon oxides, and nitrogen oxides (NOx).
  • Extinguishing Methods: Use water spray to knock down gases/powder. Prevent fire-extinguishing water from entering surface or ground water systems. Remove containers from the danger zone and cool with water.
  • Protective Equipment: Firefighters should wear self-contained breathing apparatus and suitable protective clothing to prevent skin contact.

6. ACCIDENTAL RELEASE MEASURES

  • Personal Precautions: Do not breathe powder or aerosols. Keep away from heat and ignition sources. Evacuate the area and consult an expert if necessary. Use personal protection as recommended in Section 8.
  • Environmental Precautions: Prevent the product from entering drains.
  • Methods for Cleanup: Cover drains. Collect, bind, and pump off spills. Observe material restrictions. Take up with absorbent material suitable for powder (e.g., Chemizorb®). Clean the affected area and dispose of waste properly.

7. HANDLING AND STORAGE

  • Handling: Observe label precautions. Keep away from open flames, hot surfaces, and sources of ignition. Take measures to prevent static discharge.
  • Storage: Keep the container tightly closed in a cool, well-ventilated place.
  • Storage Class: 10, Combustible powder.
  • Storage Temperature: Refer to the product label for recommended storage conditions.
  • Stability: The product is hygroscopic.

8. EXPOSURE CONTROLS/PERSONAL PROTECTION

Workplace Control Parameters:

  • Dimethyl sulphoxide (CAS 67-68-5): TWA of 250 ppm (US WEEL).

Engineering Measures: No specific data provided for this section.

Personal Protective Equipment:

  • Respiratory Protection: Required when powder/aerosols are generated. Recommended Filter type A (acc. to DIN 3181).
  • Hand Protection: Full contact: Chloroprene gloves (0.65 mm thickness, >480 min breakthrough). Splash contact: Latex gloves (0.6 mm thickness, >240 min breakthrough).
  • Eye Protection: Safety glasses.
  • Skin and Body Protection: Flame-retardant, antistatic protective clothing.
  • Hygiene Measures: Change contaminated clothing and wash hands after handling the substance.

9. PHYSICAL AND CHEMICAL PROPERTIES

  • Appearance: powder
  • Color: clear
  • Odor/Odor Threshold: N/A
  • pH: N/A
  • Melting/Boiling Point: N/A
  • Flash Point: 189 °F / 87 °C
  • Evaporation Rate: N/A
  • Flammability (solid, gas): N/A
  • Flammability (powder): N/A
  • Self-ignition: 572 - 576 °F / 300 - 302 °C at 1,013 hPa
  • Explosion Limits: Upper: 63.0 %(V); Lower: 1.8 %(V)
  • Vapor Pressure/Density: N/A
  • Relative Density: N/A
  • Solubility: Miscible in water at 77 °F / 25 °C
  • Partition Coefficient (n-octanol/water): N/A
  • Autoignition/Decomposition Temperature: N/A
  • Viscosity: N/A
  • Explosive Properties: Not classified as explosive
  • Oxidizing Properties: None
  • Particle Size: N/A

10. STABILITY AND REACTIVITY

  • Reactivity: Forms explosive mixtures with air upon intense heating.
  • Chemical Stability: The product is hygroscopic.
  • Possibility of Hazardous Reactions: Risk of explosion with various substances including acetylidene, organic halides, perchlorates, acid chlorides, nitrates, hydrides, and strong oxidizing agents. Exothermic reactions occur with boron compounds, potassium, sodium, and strong acids. Risk of ignition with potassium permanganate.
  • Conditions to Avoid: Strong heating.
  • Incompatible Materials: Various plastics and metals.
  • Hazardous Decomposition Products: Refer to Section 5.

11. TOXICOLOGICAL INFORMATION

Mixture Toxicity:

  • Acute Toxicity: N/A for oral, inhalation, or dermal routes.
  • Skin/Eye Irritation: Possible slight irritation.
  • Sensitization/Mutagenicity/Reproductive Toxicity: N/A.
  • Carcinogenicity: No components present at ≥ 0.1% are identified as carcinogens by IARC, NTP, or OSHA.
  • Symptoms: Potential CNS disorders, nausea, tiredness, and headache. May cause damage to the liver and kidneys. May accelerate skin absorption of other materials.

Component Data (Dimethyl sulphoxide):

  • LD50 Oral (Rat): 28,300 mg/kg
  • LC0 Inhalation (Rat): > 5.33 mg/l (4 h)
  • LD50 Dermal (Rat): 40,000 mg/kg
  • Irritation: Slight skin and eye irritation (Rabbit).
  • Sensitization: Negative (Guinea pig/Mouse).
  • Mutagenicity: Negative in Ames test, sister chromatid exchange assay, and chromosome aberration tests.

12. ECOLOGICAL INFORMATION

Ecotoxicity:

  • Product: N/A.
  • Dimethyl sulphoxide: LC50 (Zebra fish) > 25,000 mg/l (96 h); EC50 (Daphnia magna) 24,600 mg/l (48 h); ErC50 (Green algae) 17,000 mg/l (72 h).

Persistence and Degradability:

  • Dimethyl sulphoxide: Not readily biodegradable (31% biodegradation over 28 days). Hydrolyzes readily in water.

Bioaccumulative Potential:

  • Dimethyl sulphoxide: log Pow: -1.35; bioaccumulation is not expected.

Mobility in Soil: N/A.

Other Adverse Effects: N/A.

13. DISPOSAL CONSIDERATIONS

Waste Treatment Methods:
Waste must be disposed of in accordance with national and local regulations. Chemicals should be left in their original containers and not mixed with other waste. Handle uncleaned containers with the same precautions as the product itself.

14. TRANSPORT INFORMATION

  • IATA-DGR: Not regulated as a dangerous good.
  • IMDG-Code: Not regulated as a dangerous good.
  • 49 CFR Road:
    • UN/ID/NA number: NA 1993
    • Proper shipping name: Combustible powder, n.o.s. (dimethyl sulphoxide)
    • Class: CBL
    • Packing group: III
    • Labels: None
    • Marine pollutant: No
  • Transport in Bulk: Not applicable for product as supplied.

15. REGULATORY INFORMATION

CERCLA Reportable Quantity
This material does not contain any components with a CERCLA RQ.
SARA 304 Extremely Hazardous Substances Reportable Quantity
This material does not contain any components with a section 304 EHS RQ.
SARA 302 Extremely Hazardous Substances Threshold Planning Quantity
This material does not contain any components with a section 302 EHS TPQ.
SARA 313 : This material does not contain any chemical
components with known CAS numbers that exceed the
threshold (De Minimis) reporting levels established by
SARA Title III, Section 313.
US State Regulations
Massachusetts Right To Know
No components are subject to the Massachusetts Right to Know Act.
Maine Chemicals of High Concern
Product does not contain any listed chemicals
Vermont Chemicals of High Concern
Product does not contain any listed chemicals
Washington Chemicals of High Concern
Product does not contain any listed chemicals
The ingredients of this product are reported in the following inventories:
TSCA : Product contains substance(s) not listed on TSCA
inventory.
TSCA list
No substances are subject to a Significant New Use Rule.
No substances are subject to TSCA 12(b) export notification requirements.

16. OTHER INFORMATION

Revision Date: 2026/05/28
Further Information: The information provided is believed to be correct but is not exhaustive and should be used only as a guideline based on current knowledge. It does not represent a guarantee of the properties of the product. Selleck Chemicals Corporation and its Affiliates shall not be held liable for any damage resulting from handling or contact with the product.

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