CAS No. 66357-35-5
Batch:
Purity:98
Chemical Structure
Check the
Ranitidine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (E)-1-N'-[2-[[5-[(dimethylamino)methyl]furan-2-yl]methylsulfanyl]ethyl]-1-N-methyl-2-nitroethene-1,1-diamine | |
|---|---|---|
| CAS Number | 66357-35-5 | |
| Molecular Formula |
C13H22N4O3S |
|
| Molecular Weight (MW) | 314.40 | |
| SMILES | CNC(=C[N+](=O)[O-])NCCSCC1=CC=C(O1)CN(C)C | |
| InChIKey | VMXUWOKSQNHOCA-UKTHLTGXSA-N |
Ranitidine (AH-19065) is a potent and selective histamine H2 receptor antagonist. By competitively binding to H2 receptors on gastric parietal cells, it inhibits histamine-stimulated activation of adenylate cyclase and intracellular cAMP production. This blockade suppresses acid secretion driven by histamine and reduces stomach acid release, making it a key tool for investigating histamine signaling pathways and gastric secretory mechanisms in preclinical models. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
63 mg/mL
(200.38 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.