SMILES:

OC1=C(Br)C=C(C=C1Br)\C=C2/C(=O)NC3=C2C=C(Cl)C=C3
Raf inhibitor 2 Chemical Structure
Chemical Structure
Check the Raf inhibitor 2 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (3Z)-5-chloro-3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-1H-indol-2-one
CAS Number 220904-99-4
Molecular Formula

C15H8Br2ClNO2
Molecular Weight (MW) 429.49
SMILES OC1=C(Br)C=C(C=C1Br)\C=C2/C(=O)NC3=C2C=C(Cl)C=C3
InChIKey MPIHOJMBMIMKAJ-KMKOMSMNSA-N

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 86 mg/mL (200.23 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.