CAS No. 926037-48-1
Batch:
Purity:99.42
Chemical Structure
Check the
Radotinib
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyrazin-2-ylpyrimidin-2-yl)amino]benzamide | |
|---|---|---|
| CAS Number | 926037-48-1 | |
| Molecular Formula |
C27H21F3N8O |
|
| Molecular Weight (MW) | 530.50 | |
| SMILES | CC1=C(C=C(C=C1)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)N3C=C(N=C3)C)NC4=NC=CC(=N4)C5=NC=CN=C5 | |
| InChIKey | DUPWHXBITIZIKZ-UHFFFAOYSA-N |
Radotinib is a selective BCR-ABL1 tyrosine kinase inhibitor with an IC50 of. By binding to the ATP-binding site of the BCR-ABL1 kinase domain, it effectively blocks the constitutive tyrosine phosphorylation of downstream signaling intermediates, including STAT5, AKT, and ERK. This inhibition disrupts survival signals, resulting in impaired cell proliferation and the induction of apoptosis in BCR-ABL1-expressing chronic myeloid leukemia cells.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(188.5 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.