CAS No. 496054-87-6

Batch: Purity:99.38
Check CoA
Radiprodil (RGH-896) Chemical Structure
Chemical Structure
Check the Radiprodil (RGH-896) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 496054-87-6
Molecular Formula

C21H20FN3O4
Molecular Weight (MW) 397.40
SMILES C1CN(CCC1CC2=CC=C(C=C2)F)C(=O)C(=O)NC3=CC4=C(C=C3)NC(=O)O4

Ordering Information

Biological Activity

Radiprodil (RGH-896) is an NR2B-selective N-methyl-D-aspartate (NMDA) receptor antagonist. By selectively binding and inhibiting NR2B-containing NMDA receptor complexes, it modulates glutamate-driven excitatory signaling and downstream intracellular calcium influx pathways. This targeted receptor antagonism results in the attenuation of spinal central sensitization and reduced nociceptive signaling, contributing to its functional effects in preclinical neuropathic pain and neuroprotection models. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 79 mg/mL (198.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.