CAS No. 312-84-5

Batch: Purity:99.57
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(R)-Serine Chemical Structure
Chemical Structure
Check the (R)-Serine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 312-84-5
Molecular Formula

C3H7NO3
Molecular Weight (MW) 105.09
SMILES C(C(C(=O)O)N)O

Ordering Information

Biological Activity

(R)-Serine (D-serine) is an endogenous amino acid enantiomer that functions as an obligatory co-agonist at the glycine binding site of N-methyl-D-aspartate receptors (NMDARs). Activation of the NMDAR glycine site by (R)-Serine facilitates receptor channel opening upon glutamate binding, thereby driving downstream excitatory neurotransmission, synaptic plasticity, long-term potentiation, neurotoxicity, and neuronal cell migration. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 21 mg/mL
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.