CAS No. 1798331-92-6
Batch:
Purity:99.73
Chemical Structure
Check the
QX77
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | N-[4-(7-chloro-2H-1,4-benzoxazin-3-yl)phenyl]acetamide | |
|---|---|---|
| CAS Number | 1798331-92-6 | |
| Molecular Formula |
C16H13ClN2O2 |
|
| Molecular Weight (MW) | 300.74 | |
| SMILES | CC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=C(C=C3)Cl)OC2 | |
| InChIKey | PYCTUCLCTVWILY-UHFFFAOYSA-N |
Biological Activity
QX77 is a small-molecule activator of chaperone-mediated autophagy (CMA). By enhancing CMA activity, QX77 upregulates the expression of lysosome-associated membrane protein 2A (LAMP2A) and Rab11, key regulators of lysosomal targeting and intracellular trafficking. This activation promotes the selective degradation of substrate proteins through the CMA pathway, mitigating cellular stress and protecting against protein aggregation-induced toxicity. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
15 mg/mL
(49.87 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.