CAS No. 89-00-9
Batch:
Purity:99.16
Chemical Structure
Check the
Quinolinic acid
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | pyridine-2,3-dicarboxylic acid | |
|---|---|---|
| CAS Number | 89-00-9 | |
| Molecular Formula |
C7H5NO4 |
|
| Molecular Weight (MW) | 167.12 | |
| SMILES | C1=CC(=C(N=C1)C(=O)O)C(=O)O | |
| InChIKey | GJAWHXHKYYXBSV-UHFFFAOYSA-N |
Quinolinic acid is a neuroactive kynurenine pathway metabolite that acts as an agonist of the N-methyl-D-aspartate (NMDA) receptor. By selectively stimulating NMDA receptors, it promotes neuronal excitation, glutamate release, and intracellular calcium influx. Accumulation of quinolinic acid induces excitotoxicity, lipid peroxidation, and neuronal cell death, contributing to neurodegenerative processes and central nervous system pathology. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
25 mg/mL
(149.59 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 3 mg/mL |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.