CAS No. 82586-55-8
Batch:
Purity:99.36
Chemical Structure
Check the
Quinapril HCl
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | (3S)-2-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid;hydrochloride | |
|---|---|---|
| CAS Number | 82586-55-8 | |
| Molecular Formula |
C25H30N2O5.HCl |
|
| Molecular Weight (MW) | 474.98 | |
| SMILES | CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2CC3=CC=CC=C3CC2C(=O)O.Cl | |
| InChIKey | IBBLRJGOOANPTQ-JKVLGAQCSA-N |
Biological Activity
Quinapril HCl is a potent angiotensin-converting enzyme (ACE) inhibitor that functions as a prodrug converted in vivo to its active diacid metabolite, quinaprilat. Inhibition of ACE disrupts the renin-angiotensin-aldosterone system by preventing the enzymatic cleavage of angiotensin I into angiotensin II, which subsequently reduces downstream vasoconstriction and attenuates aldosterone secretion to modulate cellular signaling involved in vascular tone and electrolyte homeostasis.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
94 mg/mL
(197.9 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 94 mg/mL |
| Ethanol | 94 mg/mL |
| DMSO |
95 mg/mL
(200.0 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 95 mg/mL |
| Ethanol | 95 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
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Note: Technical data last updated: Sep 1, 2026.